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1、中华疾病控制杂志2011年10月第15卷第10期885帕金森病患者的社会认知功能损害的研究胡盼盼,陈先文,周珊珊,王卫华,汪凯摘要目的通过对帕金森病(parkinsondisease,PD)患者社会认知情况的研究,探讨PD患者是否存在社会认知能力下降,进一步验证基底节参与社会认知加工的假说。方法选取确诊的PD患者30例(服用美多巴0.5~3年)和年龄、教育程度相匹配的健康成人36例,采用非言语的(眼区情绪识别)和言语的(失言觉察)社会信息感知测验,对其社会认知能力进行神经心理学研
2、究。结果PD组与对照组在失言觉察总分上的差异有统计学意义(PD组,对照组分别为:27.036.11,36.893.81,Z=-5.79,P<0.001),提示PD患者的心理状态的理解能力低于正常人;而PD组的眼区情绪识别能力与对照组的差异无统计学意义,可能与美多巴的替代治疗有关(PD组,对照组喜、惊、恐、悲、厌、怒的正确识别得分分别为:19.331.06,17.901.90,15.672.45,16.232.60,15.802.07,15.932.80;19.220.87,17
3、.801.45,15.361.76,16.272.08,15.941.80,15.971.82;Z分别为-0.85,-0.67,-0.42,-0.19,-0.39,-0.23;P分别为0.395,0.500,0.676,0.850,0.694,0.820)。Pearson相关分析显示,Hoehn-Yahr分级与眼区情绪识别中的6种基本情绪、失言觉察任务得分均无明显相关性(均有P>0.05)。结论PD患者存在社会认知功能损害,PD的主要病变在基底节,提示基底节参与了社会认知的加工。关键
4、词帕金森病;基底神经节;认知障碍中图分类号R742.5文献标识码A文章编号1674-3679(2011)10-0885-03AstudyofsocialcognitiondeficitsinpatientswithparkinsondiseaseHUPan-pan,CHENXian-wen,ZHOUShan-shan,WANGWe-ihua,WANGKai.DepartmentofNeurology,theFirstAffiliatedHospitalo
5、fAnhuiMedicalUni-versity,Hefei230022,ChinaAbstractObjectiveToexploretherelationshipbetweensocialcognitionandsocialfunctioningofparkinsondis-ease,andtotestthehypothesisthatthebasalgangliaisinvolvedinthenetworkofsocialcognition.Methods30PDpa-tient
6、sand36age-andeducation-matchedhealthycontrolswereenrolledinthesocialcognitiontests.Socialcognitionabil-itiesweremeasuredwithtwoneuropsychologicaltasks:eyeemotionrecognition(happy,surprise,fear,sad,disgust,anger)andfauxpasrecognitiontask.ResultsPatien
7、tswithparkinsondiseasesshowedalargeandhighlysignificantdeficitinthefauxpastask(PD,Controls:27.036.11,36.893.81,Z=-5.79,P<0.001).Therewasnosignif-icantdifferencebetweenparkinsondiseasesgroupandcontrolgroupineyeemotionrecognition(happy,surprise,fear,s
8、ad,disgust,anger:Z=-0.85,-0.67,-0.42,-0.19,-0.39,-0.23,P=0.395,0.500,0.676,0.850,0.694,0.820,respectively).CorrelationanalysisrevealednorelationamongHoehn-Yahrstage,eyeemotionsandfauxpas.ConclusionsTheresultsconfirmthattherearedeficitsofsocia
