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页数:5页
时间:2019-05-24
《单侧全膝关节置换术后依诺肝素与利伐沙班抗凝效果的随机对照研究》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、万方数据《中国骨与关节外科》2012年6月第5卷第3期ChineseJournalofBoneandJointSurgeryV01.5,No.3,Jun2012‘临床论著。文章编号:1674一1439(2012)06一0198∞5单侧全膝关节置换术后依诺肝素与利伐沙班抗凝效果的随机对照研究王炜翁习生林进+金今钱文伟邱责兴(中国医学科学院北京协和医学院北京协和医院骨科,北京100730)背景:全膝关节置换(totalkneeanhroplas吼TKA)术后使用低分子肝素抗凝已被证实具有较好的有效性和安全性,而新的口服抗凝药物一利伐沙班在中国患者中的临床效果
2、有待证实。目的:分析依诺肝素与利伐沙班在一期单侧TKA术后的抗凝效果。方法:2010年1月至2010年4月因膝关节骨关节炎(osteoanllritis,0A)行一期单侧TKA患者75例,前瞻性随机分为A组(术后使用2周依诺肝素抗凝)、B组(术后先后使用2周依诺肝素抗凝及2周利伐沙班抗凝)和C组(术后使用4周利伐沙班抗凝)。结果:3组患者间在平均年龄、体重指数、术前及术后2周HSS评分、手术时间、术后2周下肢周径变化最大值等指标方面无显著性差异;术后2周时下肢静脉彩超结果均未发现明显血栓形成,但A组术后4周时1例患者出现术侧腓肠肌内肌间静脉血栓,经单纯抗
3、凝治疗6周后血栓消失。术后2周内A组及B组术后皮下淤斑最大面积显著大于C组(P4、na11driVaroxabanforunilateraltotalknee拙0plas够WangWei,WengXisheng,LinJin+,JinJin,QianWenwei,QiuGuixing(DepamllentofOrthopaedics,PekingUnionMedicalC01legeHospital,CAMSandPUMC,Beijing100730,China)Backgr01md:Lowmolecularhep撕nispmVedtobee能ctiveandsafeforpmphyla)【isaRertotalkneearthr叩l5、as够(TKA),whilemeneworalanticoagLll柚t,rivaroxaball,needsclinicalverification,especiallyforChinesepatients.objective:Theaimofmepresentsttldyistoevaluatetheamicoagulationofenox印撕nVersusriVaroxabaninunilatemlTKApatients.Methods:Consccutive75patientswithgonar出ritisunderwentunilateralT6、KAinol】rinstitutei11mefirst4monthsof2010andwererarIdomlydividedto印upA①ost-叩erative2weeksofenoxap耐n),铲oupB(post-operatiVe2weeksofenox叩a一血followedby2weeksofrivarox曲锄)and掣oupc(post-opemtive4weeksofriVaroxaball).Iksl7、1ts:Therewerenosignmcantdi妊brencesbetweenmethree酽011psonage,bodywei8、ghtindeX,pre-andpost—operatiVe(2we6ks)HSSscores.Neitherweret11e叩eratingtime,maXimalchaIlgesofpost-operatiVe(in2weeks)circumferemial1eng吐lof出i曲andl唔111erewasno廿u.ombosiSdetec坂lbyDoppler2weeksafteroperation,but1casedevel叩edin仃a—muscularvein4weeks撕eropemtion,whichdisappeareda舭ranome9、r6weeksofaIlticoaglllation.111emaximalar
4、na11driVaroxabanforunilateraltotalknee拙0plas够WangWei,WengXisheng,LinJin+,JinJin,QianWenwei,QiuGuixing(DepamllentofOrthopaedics,PekingUnionMedicalC01legeHospital,CAMSandPUMC,Beijing100730,China)Backgr01md:Lowmolecularhep撕nispmVedtobee能ctiveandsafeforpmphyla)【isaRertotalkneearthr叩l
5、as够(TKA),whilemeneworalanticoagLll柚t,rivaroxaball,needsclinicalverification,especiallyforChinesepatients.objective:Theaimofmepresentsttldyistoevaluatetheamicoagulationofenox印撕nVersusriVaroxabaninunilatemlTKApatients.Methods:Consccutive75patientswithgonar出ritisunderwentunilateralT
6、KAinol】rinstitutei11mefirst4monthsof2010andwererarIdomlydividedto印upA①ost-叩erative2weeksofenoxap耐n),铲oupB(post-operatiVe2weeksofenox叩a一血followedby2weeksofrivarox曲锄)and掣oupc(post-opemtive4weeksofriVaroxaball).Iksl
7、1ts:Therewerenosignmcantdi妊brencesbetweenmethree酽011psonage,bodywei
8、ghtindeX,pre-andpost—operatiVe(2we6ks)HSSscores.Neitherweret11e叩eratingtime,maXimalchaIlgesofpost-operatiVe(in2weeks)circumferemial1eng吐lof出i曲andl唔111erewasno廿u.ombosiSdetec坂lbyDoppler2weeksafteroperation,but1casedevel叩edin仃a—muscularvein4weeks撕eropemtion,whichdisappeareda舭ranome
9、r6weeksofaIlticoaglllation.111emaximalar
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