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1、中国眼耳鼻喉科杂志2009年5月第9卷第3期157·临床研究·玻璃酸钠滴眼液联合0.02%氟米龙滴眼液治疗急性结膜炎后干眼症叶锌铭吴伯乐【摘要】目的探讨玻璃酸钠滴眼液联合0.02%氟米龙滴眼液治疗急性结膜炎后干眼症的临床效果。方法选择2006年6月至2008年6月患急性结膜炎后经确诊的干眼症患者189例(285眼),将其随机分成A组91例(136眼)和B组98例(149眼)。A组用玻璃酸钠滴眼液治疗,B组用玻璃酸钠和0.02%氟米龙滴眼液治疗,比较两组患者的症状缓解时间、泪膜破裂时间(breakuptimeoftearfilm,BUT)、
2、角膜荧光素染色(fluo2rescencestaining,FL)、基础泪液分泌试验(SchirmerⅠtest,SIT)。结果两组患者自觉症状均有不同程度减轻,部分病例症状消失。A组痊愈32例(48眼,35.29%),好转43例(69眼),总有效率86.02%,无效16例(19眼)。症状最快5d缓解,8d内症状缓解率42.6%。B组痊愈76例(121眼,81.21%),好转22例(28眼),总有效率100%。症状最快2d缓解,8d缓解率78.2%。两组总有效率差异有统计学意义(t=4.79,P<0.01),治愈率差异有统计学意义(t=7
3、.89,P<0.01)。结论玻璃酸钠联合0.02%氟米龙滴眼液治疗急性结膜炎后干眼症疗效确切,明显优于单纯应用玻璃酸钠滴眼液。(中国眼耳鼻喉科杂志,2009,9:1572159)【关键词】玻璃酸钠;氟米龙;干眼症;急性结膜炎Effectoftopicalhyaluronatecombinedwith0.02%topicalflurometholoneonthetreatmentofdryeyesafteracuteconjunctivitisYEXin2ming,WUBo2le.DepartmentofOphthalmology,Lish
4、uiPeople′sHospital,Lishui323000,ChinaCorrespondingauthor:YEXin2ming,Email:yxm19722000@yahoo.com.cn【Abstract】ObjectiveToobservetheeffectofhyaluronate(HA)eyedropscombinedwith0.02%fluro2metholoneeyedropsonthetreantmentofdryeyesafteracuteconjunctivitis.MethodsOnehundredandeig
5、hty2ninepa2tients(285eyes)withdryeyesafteracuteconjunctivitisacceptedfromJun2006toJun2008wererandomlydividedintogroupA(91cases,86eyes)andgroupB(98cases,149eyes).ThepatientsweretreatedwithHAingroupAandwithtopicalHAand0.02%topicalflurometholoneingroupB.Thetimeofsymptomrelie
6、f,breakuptimeoftearfilm,fluo2rescencestainingandSchirmerItestwasmeasuredrespectively.ResultsIngroupA,32patients(48eyes,35.29%)werecuredand43patients(69eyes)wereimproved,withthetotaleffectiveratebeing86.02%.Theleasttimeofsymp2tomrelievedwas5daysandtherewere42.6%patientsimp
7、rovedduring8days.IngroupB,76patientswerecured(121eyes,81.21%),22patients(28eyes)wereimproved,withthetotaleffectiveratebeing100.0%.Theleastdaysofsymptomreliefwas2days.Serenty2enghtpointtwopercentpatientsimprovedduring8days.Therewassignificantdiffe2renceintherecoveryrate(t=
8、7.89,P<0.01)andthetotaleffectiverate(t=4.79,P<0.01)betweengroupAandgroupB.ConclusionsHAcombinedw
