甲磺酸倍他司汀治疗内耳缺血相关性眩晕的疗效研究.pdf

《甲磺酸倍他司汀治疗内耳缺血相关性眩晕的疗效研究.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、FEATURE甲磺酸倍他司汀治疗内耳缺血相关性眩晕的疗效研究TheeffectofbetahistinemesylateasatreatmenttovertigoinducedbyinnerearischemiaTheeffectofbetahistinemesylateasatreatmenttovertigoinducedbyinnerearischemia吴子明，张素珍，刘兴健，陈艾婷，冀飞，杨伟炎，韩东一【摘要】目的通过观察良性阵发性位置性眩晕（benignvertigoandtostudythecausalrelationsh

2、ipsofdosage.positionalparoxysmalvertigo，BPPV）、后循环缺血MethodNinetycasesofBPPV,PCIandMVwith30casefor（posteriorcirculationischemia，PCI）、偏头痛性眩晕eachdiseasewererecruitedfortheexperiment.Patientswith（migrainousvertigo，MV）、青少年良性眩晕在服用不同eachdiseasewerethendividedinto2groups,15casein

3、剂量的甲磺酸倍他司汀后的临床表现，了解甲磺酸倍他司汀eachgroup.Group1wastreatedwithbetahistinemesylate治疗内耳缺血性眩晕的疗效。方法BPPV、PCI、MV各306mg3/d,Group2withbetahistinemesylate12mg3/d.例，分成2组。组一：甲磺酸倍他司汀6mg，3/日；组二：Twenty-fivepatientswithteenagerbenignparoxysmalvertigo甲磺酸倍他司汀12mg，3/日，治疗均为期1个月。观察量-效weregivenbet

4、ahistinemesylate,6mg3/dfordurationof1关系。青少年良性阵发性眩晕25例不分组，甲磺酸倍他司汀month.Highstimulatingrateofauditorybrainstemresponse6mg3/日，服药治疗1月。分别观察治疗前后高刺激听性脑干(ABR)anddizzinesshandicapinventory(DHI)were测听（auditorybrainstemresponse，ABR）和眩晕残障程度administeredandcomparedbeforeandafteradmini

5、stration（dizzinesshandicapinventory，DHI）的变化。结果四类ofbetahistinemesylate.ResultsThesymptomsofthe眩晕治疗后症状减轻，高刺激ABR和DHI均有改善，而眼动异patientswerereduced.BothhighstimulatingrateABRand常变化不明显。连续用药1个月后，BPPV、PCI、MV三类患DHIwereimproved,whereastheabnormalityofocular者12mg，3/日方案疗效优于6mg，3/日方案。

6、青少年良性眩motionremained.Onemonthaftertreatment,thetherapeutic晕6mg，3/日方案也获得满意疗效。结论甲磺酸倍他司汀对protocolof12mg3/dwasbetterthanthatof6mg3/d.The良性阵发性位置性眩晕、后循环缺血、偏头痛性眩晕和青少年protocolof6mg3/dfor1monthalsoindicatedsatisfactory良性眩晕等与内耳低灌注有关的眩晕有较好的治疗作用，并表treatmentresultsonteenagerbenignpar

7、oxysmalvertigo.现出量效关系，12mg，3/日方案疗效优于6mg，3/日方案。ConclusionThecurativeeffectofbetahistinemesylateon【关键词】甲磺酸倍他司汀；内耳；缺血；眩晕BPPV,PCI,MVandteenagerbenignparoxysmalvertigowas【Abstract】ObjectiveToobservetheeffectofbetahistinesatisfactory.Thetherapeuticprotocolof12mg3/dwasmoremesyl

8、ateasatreatmenttobenignpositionalparoxysmaleffectivethanthatof6mg3/d.vertigo(BPPV),posteriorcirculation