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1、第23卷第2期航天医学与医学工程Vol.23No.22010年4月SpaceMedicine&MedicalEngineeringApr.2010·学术论著·360d头低位卧床对人体膝关节软骨磁共振T2值的影响12121231112顾华,刘跃,潘振宇,万玉民,王双坤,王红晖,申皓,郭晓娟,郭佑民,翟仁友,李莹辉(1.北京朝阳医院,北京100020;2.中国航天员科研训练中心航天细胞分子生物学实验室100094;3.通用电气(中国)医疗集团北京100176)摘要:目的基于MRT2map技术研究60d模拟失重条件对人体膝关节软骨
2、T2值的影响。方法7名健康男性头低位-6°卧床60d,应用1.5T磁共振扫描仪进行卧床前后膝关节矢状位多回波多层面序列扫描,使用profile软件测量实验前后膝关节非承重、承重软骨,髌软骨的T2弛豫时间,采用配对t检验比较实验前后软骨T2值改变。结果卧床实验前后软骨T2值具有相同的空间分布形态。60d模拟失重条件下胫骨内外侧髁承重软骨、股骨非承重软骨卧床后软骨深部T2值有降低趋势,近表面T2值有升高趋势,但是只在胫骨外侧髁承重软骨距骨软骨下骨质0.3处、胫骨内侧髁承重软骨距骨软骨下骨质0.0,0.1处、股骨非承重软骨距骨软骨
3、下骨质0.0处T2值降低有统计学差异(P<0.05);而胫骨内侧髁承重软骨距骨软骨下骨质0.4,0.5处T2值升高有统计学差异(P<0.05)。其余各处软骨实验前后T2值未见统计学差异。结论-6°头低位卧床60d前后膝关节软骨T2值空间分布相似,胫骨内外髁承重软骨、股骨非承重软骨深部T2值发生改变,但总体来看头低位卧床对膝关节软骨T2特性影响较小。关键词:头低位卧床;膝关节;关节软骨;磁共振成像;T2弛豫时间中图分类号:R856文献标识码:A文章编号:100220837(2010)0220090205Effectsof60d
4、(-6°)Head2downBedRestonMRT2RelaxationTimesofArticularCartilageinHumanBeing1GUHua,LIUYue,PANZhen2yu,WANYu2min,WANGShuang2kun,WANGHong2hui,SHENHao,GOUXiao2juan,GUOYou2min,ZHAIRen2you,LIYing2hui.SpaceMedicine&MedicalEngineering,2010,23(2):90～94Abstract:ObjectiveTostud
5、ywithMRIT2relaxationtimewhether60dhead2down(-6°)bedrestaffectsthespatialdependencyofarticularcartilageT2.MethodsDuringsevenyounghealthymenbeforeandafter60dhead2down(-6°)bedrest,quantitativemagneticresonance(MR)T2mapsofkneearticularcartilagewereobtainedwithamultiech
6、o,spin2echosequencewitha1.52TMRimager.T2profilesofthepatellar,distalfemoralweight2andnon2weight2bearingandproximaltibialweight2bearingwereobtained.TheT2valuesofcartilagebetweenbeforeandafterbedrestwerecomparedwithpaired2samplesttest.ResultsTherewasnodifferenceinpat
7、ternofspatialvariationcartilageT2betweenbeforeandafterbedrest.TherewasatrendtowarddecreaseofT2relaxationtimevaluesatdeepofcartilageandincreaseatsurfaceofcartilageafterbedrest.Afterbedresttherewasastatisticallysignificant(P<0.05)decreaseinT2valueoflateralandmedialti
8、bialcartilage,andnon2weight2bearingdistalfemoralcartilageinthedeepzoonatnormalizeddistanceof0.3(lateraltibial),0.0and0.1(medialtibial),aswellas0.
