资源描述：
《小檗碱对兔动脉粥样硬化及其血脂的影响》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、·204·中国脑血管病杂志2006年5月18日第3卷第5期ChinJCerebrovascDis,May118,2006,Vol13,No15·降脂治疗研究·小檗碱对兔动脉粥样硬化及其血脂的影响左彦方郭毅姜昕李方明王启章【摘要】目的研究中药小檗碱调节血脂及抗动脉粥样硬化的作用。方法将18只雄性新西兰兔随机分为对照组:喂食普通兔料;高脂模型组:喂食高脂饲料;小檗碱组:喂食高脂饲料并给予小檗碱干预。饲养12周后处死动物,利用全自动生化分析仪酶法测定兔血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL2C)、低密度脂蛋白胆固醇(LDL2C)水
2、平;取主动脉进行病理学检查。结果病理学大体观察显示,对照组、高脂模型组和小檗碱组主动脉壁脂质斑块面积占整条主动脉内壁面积的百分比分别为0%、(5916±1317)%和(3613±1615)%,组间比较差异有显著性(P<0101);光镜下动脉粥样硬化斑块多参数分析显示,斑块最大厚度、斑块平均厚度、管腔狭窄度和斑块所占周径比值4个指标各组间两两比较差异有显著性(P<0101)。给予小檗碱干预组的血清总胆固醇和LDL2C水平分别比高脂模型组降低了28188%和40194%,HDL2C、三酰甘油水平差异无显著性。结论小檗碱能够降低血清三酰甘油和
3、LDL2C水平,并能预防动脉粥样硬化斑块的形成和发展。【关键词】小檗碱;高脂血症;动脉硬化;兔【中图分类号】R28;R543【文献标识码】AEffectsofberberineonatherosclerosisandplasmalevelsoflipidinatheroscleroticrabbitsZUOYan2fang,GUOYi,JIANGXin;LIFang2ming,WANGQi2zhang.DepartmentofNeurology,theSecondClinicalMedicalCollegeofJinanUniversi
4、ty,Shenzhen518020,ChinaCorrespondingauthor:GUOYiAbstract:ObjectiveToexaminetheeffectsofberberineonatherosclerosisandplasmalevelsoflipidinrabbits.Methods18maleNewZealandrabbitswererandomlydividedinto3groups:controlgroup,untreatedcholesterol2fedgroup,andberberinetreatedgro
5、up,whichwerefedfor12weeks.After12weeks,plasmalevelsoftotalcholesterol(TC)、triglycerides(TG)、highdensitylipoproteincholesterol(HDL2C)andlowdensitylipoproteincholesterol(LDL2C)weremeasuredenzymaticallybyautomaticfa2cilitiesandtheaortawasharvestedforpathologicmorphologyobse
6、rvation.ResultsTheaortaplaque/intimasize(P/I)was0%、(5916±1317)%and(3613±1615)%incontrol,untreatedcholesterol2fedgroupandberberinetreatedgrouprespectivelybypathologicmorphologyobservation(P<0101).Themax2imumplaquethickness,theaverageplaquethickness,thedegreeofaorticstenos
7、isandtheproportionoftheintimalcircumferenceoccupiedbyatheromaof3groupsweredifferentfromeachothersignificantly(P<0101).PlasmalevelsofTCandHDLCinberberinetreatedgroupweredecreasedsignificantly(by28188%and40194%respectively)comparedwiththatinuntreatedcholesterol2fedgroup(P<
8、0101).PlasmalevelsofHDLCandTGinberberinetreatedgroupshowednodifferencefromuntreatedcholesterol2fedgroup
