注射治疗非小细胞肺癌恶性心包积液

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1、万方数据《癌症》ChineseJournalofCancer，2006，25(4)：505—508505VP．16联合DDP心包腔内注射治疗非小细胞肺癌恶性心包积液陈丽昆1，-，徐光川1,2，梁颖1一，杨群英1一，张利娜l，2临床研究IntrapericardialInfusionofEtoposideandCisplatininTreatingMalignantPericardialEffusionofNon-smallCellLungCancerCHENLi—Kunl一，XUGuang—Chuanl一，LIANGYin91一，YA

2、NGQun—Yin91一，ZHANGLi—Nal'21．华南肿瘤学国家重点实验室．广东广州5100602．中山大学肿瘤防治中心内科．广东广州510060』．StateKeyLaboratoryofOncologyinSouthChina，Guangzhou，Guangdong，510060，P．尺．(流ina2．DepartmentofMedicalOncology，CancerCenter，SunYat—senUniversity，Guangzhou，Guangdong，510060，尸．R．China通讯作者：陈丽昆Corresp

3、ondenceto：CHENLi—KunTel：86—20—87343368E—mail：ssnow2005@163．COITI收稿日期：2005—09—19修回日期：2005—10—28[ABSTRACT]BACKGROUND＆OBJECTIVE：PericardiocentesisandintraDericardialinfusionofchemotherapeuticdrugsiSthemaintreatmentofmaliqnantpericardiaIeffusion．Thisstudywastoobservetheeffi

4、cacyandsideeffectoflnlrapericardiaIinfusionofetoposide(VP一16)andcisplatin(DDP)onmalignantpericardialeffusionofnon—smallcelllungcancer(NSCLC)．METHODS：Twenty—eightNSCLCpatientswithmalignantpericardialeffusionweretreatedwithpericardiOcentesisandintrapericardiaIinfusionofVP

5、一16(200—300mg)andDDP(80—100mg)Intravenouschemotherapyweregiven2weeksafterthepericardiocentesisRESULTS：TheoveralIresponsefOR)rateofthefirst—timetreatmentofthe28patientswas857％．withcompleteresponse(CR)rateof71．4％：theORrateOfthesecond—timetreatmentwas100％．Only4patientsneed

6、edsecond—timeDericardiocentesis．SixteenpatientsdevelopedgastrointestinaItractreaction(mainlygradel—I

7、)，12developedmyeIosuppression(mainlygrade1)，and1showedmildabnormaIoftransaminase．Forthe24ndivepatients．theoverallsurvivaItimewas14monthsforstageⅢBand109monthsforstageIV：

8、whereasforthe4patientswithrelapseddisease．theoveralfsurvivaItimewas6months(fromthetimeofrelapse)．CONCLUSION：IntrapericardiaIinfusionOfVP一16andDDPiSaneffectivetreatmentformalignantpericardiafeffusionofNSCLCKEYWORDS：Lungneoplasm；Malignantpericardialeffusion；Chemotherapy；E

9、toposide；Cisplatin【摘要】背景与目的：心包穿刺抽液后心包腔内药物治疗是治疗恶性心包积液的主要手段。本研究观察足叶乙甙(vP一16)联合顺铂(DDP)心包腔内注射治疗非小细胞肺癌恶性心包积液的疗效及不良反