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1、1112JournalofQiqiharMedicalCollege,2008,Vol.29,No.9护理园地抗生素封管预防血透患者临时中心静脉留置导管相关感染的研究刘仕艳汤颖李荣英摘要!目的评价抗生素封管对中心静脉留置导管相关感染的预防作用,探讨感染控制的有效措施。方法选择113例临时中心静脉留置导管的血透患者,随机分为两组:对照组53例采用单纯肝素封管(肝素组);实验组60例采用肝素+头孢唑啉联合封管(抗生素组)。随访两组导管相关感染的发病率并使用卡方检验进行比较。同时将肝素组和本血透中心既往中心静脉导管相关性感
2、染的发病率进行比较。结果感染共7例次,总体感染发病率为6.19%,其中肝素组3例次,感染发病率为5.66%,抗生素组4例次,感染发病率为6.67%,两组的发病率无显著性差别(P>0.05)。肝素组和既往中心静脉导管相关性感染的发病率(17.94%)有显著差异(P<0.05)。结论加用头孢唑啉封管对中心静脉留置导管相关感染的发病无明显预防作用;严格无菌操作和加强护理是降低感染、减少抗生素使用的关键措施。关键词!抗生素封管导管相关感染中心静脉留置导管血液透析Useofanantimicrobiallocksolutionforp
3、reventionofthecatheterrelatedinfectionsinhemodialysispatientswithtemporarycentralveincatheterLIUShi-yan,etal.(DepartmentofBloodpurification,ZhongshanHospital,FudanUniversity,Shanghui200032P.R.China)Abstract!ObjectiveToidentifytheefficacyofantimicrobialsolutionforprev
4、entingthecatheterrelatedinfectionsinhemodilysispatientswithtemporarycentralveincatheterandsearchforthebettercontrolmethods.MethodsOnehundred-thirteenpatientswithnewtemporaryhemodialysiscatheterswereenrolledintothestudy,andwererandomlyassignedtoreceiveeitherheparinlockso
5、lution(heparin50mg/ml)orantimicrobiallocksolution(cefazolin10mg/ml,heparin45mg/ml),patientswerefollowedup.Dataanalysiswasperformedwith2-tailedFisher'exacttest,meanwhile,thepreviouscatheterrelatedinfectionincidencewascontrastedwiththeheparingroup.ResultsSevenpatientsdev
6、elopedinfections.Totalinfectionincidencewas6.19%.thereoffifty-threepatientsintheheparingroup(5.66%),fourofsixtypatientsinthecefazolingroup(6.67%),nosignificantdifferences(P>0.05).Infectionincidenceintheheparingroupwassignificantdifferentwiththeprevious(17.94%)(P<0.05).
7、ConclusionsAntimicrobiallocksolutionswerenotthestandardheparinlockaloneinthepreventionofcatheterrelatedinfections.Keepingtherulesofsterileoperationandimprovingnursingworkmightreducetheinfections.Keywords!AntibioticlocktechniqueCatheterinfectionCentralvenouscatheter
8、Hemodialysis临时中心静脉置管因其简便、快捷、痛苦及破坏性小,血静脉内瘘成熟和肾移植前的过渡,有着不可或缺的作用。然流量大等优点,对于需要紧急处理的血液净化适应症以及动而感染是其常见的并发
