Science 2002 298 1747Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

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1、Corepressor-DependentSilencingofChromosomalRegionsEncodingNeuronalGenesVictoriaV.Lunyak,etal.Science298,1747(2002);DOI:10.1126/science.1076469Thefollowingresourcesrelatedtothisarticleareavailableonlineatwww.sciencemag.org(thisinformationiscurrentasofAugust21,2007):Acorrectionhasbeenpublishedforthi

2、sarticleat:http://www.sciencemag.org/cgi/content/full/299/5613/1663bUpdatedinformationandservices,includinghigh-resolutionfigures,canbefoundintheonlineversionofthisarticleat:http://www.sciencemag.org/cgi/content/full/298/5599/1747SupportingOnlineMaterialcanbefoundat:http://www.sciencemag.org/cgi/c

3、ontent/full/1076469/DC1AlistofselectedadditionalarticlesontheScienceWebsitesrelatedtothisarticlecanbefoundat:http://www.sciencemag.org/cgi/content/full/298/5599/1747#related-contentonAugust21,2007Thisarticlecites35articles,14ofwhichcanbeaccessedforfree:http://www.sciencemag.org/cgi/content/full/29

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5、www.sciencemag.orgthisarticleinwholeorinpartcanbefoundat:http://www.sciencemag.org/about/permissions.dtlDownloadedfromScience(printISSN0036-8075;onlineISSN1095-9203)ispublishedweekly,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenueNW,Washington,DC200

6、05.Copyrightc2002bytheAmericanAssociationfortheAdvancementofScience;allrightsreserved.ThetitleSCIENCEisaregisteredtrademarkofAAAS.RESEARCHARTICLESgenes(Fig.1B).Thus,thebindingofRESTCorepressor-DependentSilencingfunctionsinbothestablishingandmaintainingrepression(2–4).ofChromosomalRegionsOverexpres

7、sionoftheREST/NRSFinter-actiondomainofCoREST(CoREST)(6)RIDservedasadominantnegativeintheRat-1EncodingNeuronalGenescellsandresultedinthespecificderepressionoftheNaChIIgene(Fig.1C);incontrast,VictoriaV.Lunyak,1Robe