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1、Propionyl-L-CarnitineImprovesExercisePerformanceandFunctionalStatusinPatientswithClaudication*WilliamR.Hiatt,MD,JudithG.Regensteiner,PhD,MarkA.Creager,MD,AlanT.Hirsch,MD,JohnP.Cooke,MD,PhD,JeffreyW.Olin,DO,GeorgijN.Gorbunov,MD,JeffreyIsner,MD,YurijV.Lukjanov,MD,Mihail
2、Sh.Tsitsiashvili,MD,TatyanaF.Zabelskaya,MD,AntoninoAmato,MDPURPOSE:Wetestedthehypothesisthatpropionyl-L-carni-pionyl-L-carnitinegroup.After6monthsoftreatment,subjectstinewouldimprovepeakwalkingtimeinpatientswithclaudi-randomlyassignedtopropionyl-L-carnitineincreasedth
3、eircation.Secondaryaimsofthestudyweretoevaluatetheeffectspeakwalkingtimeby1626222seconds(a54%increase)asofpropionyl-L-carnitineonclaudicationonsettime,functionalcomparedwithanimprovementof756191seconds(a25%status,andsafety.increase)forthoseonplacebo(P,0.001).Similarim
4、prove-SUBJECTSANDMETHODS:Inthisdouble-blind,random-mentswereobservedforclaudicationonsettime.Propionyl-L-ized,placebo-controlledtrial,155patientswithdisablingclaudica-carnitinetreatmentsigni®cantlyimprovedwalkingdistancetionfromtheUnitedStates(n572)orRussia(n583)recei
5、vedandwalkingspeed(bytheWalkingImpairmentQuestion-eitherplaceboorpropionyl-L-carnitine(2g/dayorally)for6naire),andenhancedphysicalrolefunctioning,reducedbodilymonths.Subjectswereevaluatedatbaselineand3and6monthspain,andresultedinabetterhealthtransitionscore(bytheafter
6、randomizationwithagradedtreadmillprotocolataconstantMedicalOutcomeStudySF-36Questionnaire).Theincidencespeedof2milesperhour,beginningat0%grade,withincrementsofadverseeventsandstudydiscontinuationsweresimilarintheinthegradeof2%every2minutesuntilmaximalsymptomsoftwotrea
7、tmentgroups.claudicationforcedcessationofexercise.QuestionnaireswereusedCONCLUSIONS:Propionyl-L-carnitinesafelyimprovedtodeterminechangesinfunctionalstatus.treadmillexerciseperformanceandenhancedfunctionalstatusRESULTS:Atbaseline,peakwalkingtimewas3316171sec-inpatient
8、swithclaudication.AmJMed.2001;110:616±622.ondsintheplacebogroupand3316187secondsinthepro-q2001byExcerptaMedica,Inc.eripheral
