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1、PolymerInternational30(1993)505-511MonodisperseMicrospheresofCopolymersofGlycidylMethacrylateanditsDerivativesasMaterialsforBiomedicalApplication*ShuntaroHosaka,YasuoMurao,HideakiTamaki,SanaeMasuko,KumikoMiura&YasuroKawabataBasicResearchLaboratories,TorayIndustries,Inc.
2、,1111Tebiro,Kamakura-shi,Kanagawa248,Japan(Received12March1992;revisedversionreceived24April1992;accepted28May1992)Abstract:Monodispersemicrospheresofcopolymersofglycidylmethacrylatewerepreparedbydispersionpolymerizationinorganicmedia.Themicrospherediametercouldbeadjust
3、edintherangefrom0.5pmto5pmbychangingthemonomerconcentration,thetypeofdispersionmediumandthecontentofthecomonomers.Terpolymersofglycidylmethacrylate,2-hydroxyethylmethacrylateandtri(ethyleneglycol)dimethacrylatewereanalysedbythermaldecompositiongaschromatographyandthecom
4、positionsofthepolymersagreedwellwiththoseofthemonomermixtures.Theepoxideofthepolymermicrosphereswashydrolysedto2,/3-diolwithdilutesulphuricacidwithoutsidereactionsexcepttheslightformationofsulphate.Itwasconfirmedbythe'3CFT-NMRspectrumthatthemainstructureofthehydrolysate
5、wasthatofpoly(glycery1methacrylate).Inthereactionoftheepoxidewithammonia,thepredominantproductionoftertiaryaminewaspresumedbytherelationshipbetweentheconversionoftheepoxideandthenitrogencontentofthereactionproduct.Theaminationoftheepoxidewithsecondaryaminesresultedinthe
6、quantitativeformationofthecorrespondingtertiaryamines.Keywords:monodispersemicrospheres,polymermicrospheres,glycidylmethacry-late,hydroxylation,amination.INTRODUCTIONswelling5anddispersionpolymerization.6TheabovementionedconventionalmethodsexceptdispersionTheauthorshave
7、foundthatmonodispersemicrospherespolymerizationrequireamultisteppolymerizationofpmsizecouldbepreparedbycopolymerizationofprocess.Oneoftheadvantagesofthepolymerizationglycidylmethacrylate(abbreviatedtoGMAhereafter)methodofthepresentreportisthecapabilityofwithothermethacr
8、ylatesaddedasminorcomponentsinproducingmicrosphereslargerthan1pminonestep.anappropriateorganicmediumwithoutast
