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1、NEURALREGENERATIONRESEARCHVolume7,Issue11,April2012www.nrronline.orgCitethisarticleas:NeuralRegenRes.2012;7(11):842-848.Theroleofmicrotubule-associatedprotein1Binaxonalgrowthandneuronalmigrationinthecentralnervoussystem*☆MaoguangYang,MinfeiWu,PengXia,ChunxinWang,PengYan,QiGao,Ji
2、anLiu,HaitaoWang,XingweiDuan,XiaoyuYangDepartmentofOrthopedics,China-JapanUnionHospital,JilinUniversity,Changchun130033,JilinProvince,ChinaAbstractInthisreview,wediscusstheroleofmicrotubule-associatedprotein1B(MAP1B)anditsMaoguangYang☆,Studyingphosphorylationinaxonaldevelopmenta
3、ndregenerationinthecentralnervoussystem.MAP1Bfordoctorate,DepartmentofOrthopedics,China-Japanexhibitssimilarfunctionsduringaxonaldevelopmentandregeneration.MAP1BandphosphorylatedUnionHospital,JilinMAP1Binneuronsandaxonsmaintainadynamicbalancebetweencytoskeletalcomponents,andUniv
4、ersity,Changchunregulatethestabilityandinteractionofmicrotubulesandactintopromoteaxonalgrowth,neural130033,JilinProvince,Chinaconnectivityandregenerationinthecentralnervoussystem.Correspondingauthor:KeyWords:microtubule-associatedprotein1B;centralnervoussystem;axonalregeneration
5、;XiaoyuYang,Professor,axonaldevelopment;axonguidance;neuronalmigrationDoctoralsupervisor,Abbreviations:CNS,centralnervoussystem;MAP1B,microtubule-associatedprotein1B;GSK3β,DepartmentofOrthopedics,China-JapanUnionHospital,glycogensynthasekinase3β;PI3K,phosphatidylinositol-3kinase
6、;JNK,c-JunN-terminalkinaseJilinUniversity,Changchun130033,JilinProvince,China;XingweiDuan,M.D.,Here,wereviewrecentadvancesinourWorkinginPeople’sHospitalINTRODUCTIONunderstandingofMAP1BfunctionandofShenzhenBaoanDistrictyangxiaoyu88@sina.comregulation.Anappreciationoftheunderlying
7、AlthoughrecentevidenceindicatesthatmolecularmechanismsshouldhelpReceived:2012-02-07Accepted:2012-03-08axonalregenerationandneuralpathwayresearchersintheireffortstopromoteCNS(N20111212001/WJ)reconstructioncanoccurfollowingcentralrepairandaxonalregeneration,andleadtoYangMG,WuMF,Xi
8、aP,nervoussystem(CNS)injury,brainandeffectiveme
