泽芪汤对肝硬化门静脉高压症患者血流动力学及肝纤维化指标影响

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1、18河北中医2015年1月第37卷第1期HebeiJTCM，January2015，Vol37，No．1doi:10．3969/j．issn．1002－2619．2015．01．006泽芪汤对肝硬化门静脉高压症患者※血流动力学及肝纤维化指标的影响1郭海军佟雪飞(河北省邢台市人民医院肝病科，河北邢台054000)【摘要】目的观察泽芪汤对肝硬化门静脉高压症患者血流动力学和肝纤维化指标的影响。方法将60例肝硬化门静脉高压症患者随机分2组。2组均常规接受护肝、降酶等对症治疗，治疗组30例加服泽芪汤，对照组30例加服普萘洛尔。2组均治疗3个月后观察治疗前后肝纤维化指标透明质

2、酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ－C)、层粘连蛋白(LN)变化，并检测门静脉内径(PVD)、脾静脉内径(SVD)、门静脉血流速度(Spv)及门静脉血流量(Qpv)。结果治疗组治疗后HA、PCⅢ、Ⅳ－C、LN均下降(P＜0．05)，PVD、SVD、Spv及Qpv均改善(P＜0．05);2组治疗后HA、PCⅢ、Ⅳ－C、LN、PVD、SVD、Spv及Qpv比较差异均有统计学意义(P＜0．05)。结论泽芪汤能较好地改善肝硬化门静脉高压，降低纤维化指标。【关键词】肝硬化;高血压，门静脉;并发症;中药疗法【中图分类号】Ｒ543．053．1;Ｒ619．053．1【

3、文献标识码】A【文章编号】1002－2619(2015)01－0018－04ObservationofZeqidecoctiononhemodynamicsandliverfibrosisindexesinlivercirrhosispatientswithpor-**talhypertensionGUOHaijun，TONGXuefei．DepartmentofLiverDisease，HebeiProvinceXingtaiPeople＇sHospital，Hebei，Xingtai054000【Abstract】ObjectiveToobservetheef

4、fectofZeqidecoctiononhemodynamicsandliverfibrosisindexesinlivercirrhosispatientswithportalhypertension．Methods60cirrhoticpatientswithportalhypertensionwereran-domlydividedintotreatmentgroupandcontrolgroup．Patientsintwogroupsreceivedconventionalprotectingliver，re-ducingenzymeandothersy

5、mptomatictreatment;thepatientsinthetreatmentgroupwereaddedtoZeqidecoction，pa-tientsofthecontrolgroupreceivedoralpropranolol．Thecoursewasthreemonthsinthetwogroups．Liverfibrosismarkershyaluronicacid(HA)，procollagentypeⅢ(PCⅢ)，collagentypeⅣ(Ⅳ－C)，laminin(LN)，anddetectthediametersoftheporta

6、lvein(PVD)，splenicvein(SVD)，portalveinflowvelocity(Spv)，portalvenousbloodflow(Qpv)weremeasuredbeforeandaftertreatment．ＲesultsAftertreatment，HA，PCⅢ，Ⅳ－C，LNweredecreasedintreatmentgroup(P＜0．05)，portalveindiameter，bloodflowvelocity，bloodflowbeforeandaftertreatmentweresignificantlydifferen

7、t(P＜0．05)，comparedwiththecontrolgroupaftertreatmentalsoshowedasignificantdifference(P＜0．05)．ConclusionZeqidecoctioncanimprovethelivercirrhosiswithportalhypertension，decreasethefibro-sisindex．Curativeeffectisbetterthanthatofpropranolol，isaneffectiveprescriptionintreatinglivercirrhosisa

8、ndpor