丙酮酸乙酯对大鼠重症急性胰腺炎脑组织的保护作用

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1、学号：2012110151中图分类号：R657.5+1丙酮酸乙酯对大鼠重症急性胰腺炎脑组织的保护作用Potectivefunctionofethylpyruvateonbraintissuesinjuryassociatedwithsevereacutepancreatitis学科专业：急诊医学研究生：刘补报指导教师：李得溪教授完成时间：二O一五年五月郑重声明：本人所呈交的学位论文是在导师指导下，独立进行研究所取得的研究成果。除文中特别加以标注引用的内容外，本论文内容不包含其他个人或集体已经公开发表或撰写过的研究成果。对本文的研究做出重要贡献的个人和集体，均已在文中以明确方式标明。本人学位

2、论文与资料若有不实，愿意承担一切相关的法律责任。论文作者签名年月日本人完全了解学院有关保留、使用学位论文的规定，同意学院保留并向国家有关部门或机构送交论文的复印件和电子版。学院享有发表、复制、查阅、借阅及申请专利等权利。可以采用影印、缩印或扫描等复制手段保存和汇编学位论文。同时本人保证：毕业后发表、使用学位论文以及结合学位论文研究课题再撰写的文章，作者署名单位一律为内蒙古医科大学。论文作者签名指导教师签名年月日年月日目录中文摘要··················································································

3、·············（1）英文摘要·······························································································（2）论文题目·······························································································（4）材料与方法·········································································

4、··················（5）结果···································································································.（12）讨论···································································································.（22）结论·······························································

5、····································.（25）参考文献·····························································································.（26）文献综述·····························································································.（29）参考文献·················································

6、············································.（37）缩略语表·····························································································.（40）攻读学位期间发表文章情况………………………………………………………….…..(41)个人简历…………………………………………………………………….……………...(42)致谢…………………………………………………………………………………………(43)内蒙古医科大学硕士研究生学位论文（2015）

7、1中文摘要目的建立Wistar大鼠重症急性胰腺炎脑损伤模型，观察丙酮酸乙酯对重症急性胰腺炎脑组织中TNF-α、NF-κB和HMGB-1表达水平的影响，探讨急性重症胰腺炎并发脑损伤引起的胰性脑病的发病机制及丙酮酸乙酯对重症急性胰腺炎伴脑损伤的保护机制，为临床工作上治疗重症急性胰腺炎并发胰性脑病提供新的治疗思路。方法采用健康Wistar大鼠54只，体重200±13g，随机分为三组：正常对照组(n=18)，模型组(n=18)，