资源描述：
《生物信息学1 陈润生》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、生物信息学现状和重要研究方向陈润生E-mail:crs@sun5.ibp.ac.cnrunshengc@hotmail.comTel:86-10-64888543Fax:86-10-64871293凌伦奖E-mail:ling@sun5.ibp.ac.cnTel:86-10-64888544中国科学院生物物理研究所北京朝阳区大屯路15号背景NormalMaleFISHDifferentprobesusedtomarkeachchomosomeComputeridentifiesprobeandgivechromosomea
2、falsecolorTrisomy13PatauSyndromePatauSyndromeCleftlipandpalateExtrafingers&toespolydactylismDefectsHeartBrainKidneyMostabortLivespan<1month一.什么是生物信息学？Genomeinformaticsisascientificdisciplinethatencompassesallaspectsofgenomeinformationacquisition,processing,storage
3、,distribution,analysis,andinterpretation.它是一个学科领域，包含着基因组信息的获取、处理、存储、分配、分析和解释的所有方面。(TheU.S.HumanGenomeProject:TheFirstFiveYearsFY1991-1995,byNIHandDOE)从美国的三个国家计划说起：曼哈顿计划；阿婆罗计划；人类基因组计划。破译人类遗传密码就要读懂由30亿符号组成的100万页的“天书”GenomeshighlighttheFinitenessofthe“Parts”inBiology
4、Bacteria, 1.6Mb,~1600genes[Science269:496]Eukaryote,13Mb, ~6Kgenes[Nature387:1]199519971998Animal, ~100Mb,~20Kgenes[Science282:1945]Human, ~3Gb,~100Kgenes[???]2000?realthing,Apr‘00‘98spoofADraftSequenceoftheRiceGenome(OryzasativaL.ssp.indica)JunYu,1,2,3,4*Songnian
5、Hu,1*JunWang,1,2,5*GaneKa-ShuWong,1,2,4*SonggangLi,1,5BinLiu,1YajunDeng,1,6LiDai,1YanZhou,2,7XiuqingZhang,1,3MengliangCao,8JingLiu,2JiandongSun,1JiabinTang,1,3YanjiongChen,1,6XiaobingHuang,1WeiLin,2ChenYe,1WeiTong,1LijuanCong,1JianingGeng,1YujunHan,1LinLi,1WeiLi,1
6、,9GuangqiangHu,1XiangangHuang,1WenjieLi,1JianLi,1ZhanweiLiu,1LongLi,1JianpingLiu,1QiuhuiQi,1JinsongLiu,1LiLi,1TaoLi,1XuegangWang,1HongLu,1TingtingWu,1MiaoZhu,1PeixiangNi,1HuaHan,1WeiDong,1,3XiaoyuRen,1XiaoliFeng,1,3PengCui,1XianranLi,1HaoWang,1XinXu,1WenxueZhai,3Z
7、haoXu,1JinsongZhang,3SijieHe,3JianguoZhang,1JichenXu,3KunlinZhang,1,5XianwuZheng,3JianhaiDong,2WanyongZeng,3LinTao,2JiaYe,2JunTan,2XideRen,1XueweiChen,3JunHe,2DaofengLiu,3WeiTian,2,6ChaoguangTian,1HongaiXia,1QiyuBao,1GangLi,1HuiGao,1TingCao,1JuanWang,1WenmingZhao,
8、1PingLi,3WeiChen,1XudongWang,3YongZhang,1,5JianfeiHu,1,5JingWang,1,5SongLiu,1JianYang,1GuangyuZhang,1YuqingXiong,1ZhijieLi,1LongMao,3ChengshuZhou,8ZhenZ
