机械力致神经元损伤作用的初步研究

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1、分类号UDC学号M201575284学校代码10487密级硕士学位论文机械力致神经元损伤作用的初步研究学位申请人：邱明洁学科专业：法医病理学指导教师：董红梅教授答辩日期：2018年5月AThesisSubmittedinPartialFulfillmentoftheRequirementsforDegreeofMasterofMedicineThestudyofstretchinducedneuronalinjuryCandidate:MingjieQiuMajor:ForensicpathologySupervisor:Prof

2、.HongmeiDongHuazhongUniversityofScience&TechnologyWuhan430030,P.R.ChinaMay,2018本课题由以下基金资助：机械敏感TRP离子通道在剪切力致神经元损伤中的调控作用及在弥漫性轴索损伤法医学鉴定中的应用探索（2014年国家自然科学基金面上项目，项目编号：81471821）目录主要缩略语英汉对照·························································1中文摘要·························

3、···············································2英文摘要········································································5前言·········································································9材料与方法······························································

4、·······11实验结果········································································18讨论········································································24结论········································································28参考文献·························

5、···············································29综述··············································································33参考文献········································································47硕士在读期间发表及待发表的文章·······································56致谢·

6、·············································································57华中科技大学硕士学位论文主要缩略语英汉对照简称英文全称中文全称NF-LNeurofilamentLightChain神经丝蛋白轻链NSENeuronspecificenolase神经元特异性烯醇酶DAIdiffuseaxonalinjury弥漫性轴索损伤TBITraumaticbraininjury创伤性脑损伤TUNELTdT-mediateddUTPnickendlabel

7、ing末端脱氧核糖核苷酸转移酶介导的脱氧三磷酸尿苷缺口末端标记法MPTPMitochondrialpermeabilitytransition线粒体膜通透性转换孔poreICC/IFImmunocytochemistry/免疫细胞化学/免疫荧光ImmunofluorescenceRBreactionball收缩球PBSPhosphateBufferedSolution磷酸盐缓冲液CNSCentralNervousSystem中枢神经系统FigFigure图表1华中科技大学硕士学位论文中文摘要【研究背景】弥漫性轴索损伤（diffus

8、eaxonalinjury，DAI）是创伤性脑损伤（traumaticbraininjury，TBI）后发生的，以神经轴索广泛损伤为主要表现的病理改变。在创伤性脑损伤的住[10]院患者中占40％至50％。是闭合性颅脑损伤中最常见的病变之一。在病理上