Id2在成年大鼠脑中的表达及其影响SVZa神经干细胞发育分化的初步研究

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1、第三军医大学硕士学位论文常用英文缩写一览表缩写英文全称中文名称APSAmmoniumpersulfate过硫酸胺bFGFBasicfibroblastgrowthfactor碱性成纤维细胞生长因子bHU{Basicheli】【-loop-helix碱性螺旋．环．螺旋结构域BrdUBromodeoxyuridine溴脱氧尿嘧啶尿苷CNSCcaatralnervoussystem中枢神经系统DAB3．3’-diaminobenzidlne3。3’．二氨基联苯胺DEPCDiethylpyrocarbonate焦碳酸二乙脂DAIEMDulb

2、ecco’smodifiedeaglemedium改良的基础培养基开rCFluoresceinisothiaeyanate异硫氰酸荧光素GEAPGlialfibrfltm'yacidicprotein胶质纤维酸性蛋白Id2InhibitorofDNAbinding一2DNA结合抑制因子2LvLateralventricle侧脑室mRNAMessageRNA信使RNANestinNeuroepitheliastemcellprotein神经上皮干细胞蛋白NFNeurofilament神经丝蛋白NSCsNeuralstemcells神经

3、干细胞oBOlfactorybulb嗅球oDOpticaldensity光密度值PA(mPolyaerylamidegelelectrophoresis聚丙烯酰胺凝胶电泳PBSPhosphatebufferedsaline磷酸盐缓冲液RMSRostralmigratoryslream嘴侧迁移流第三军医大学硕士学位论文rpmm二PCRSAGESVZa咖DT3THRollperminuteReversetranscription—polymerasechainreactionSerialanalysisgeneexpressionAnt

4、eriorsubvenlricularzoneN'N，N’，NiTetramethyl-ethylenediamineTriiodothyronineTyrosinehydroxylase2每分钟转数逆转录聚合酶链式反应基因表达连续分析法室管膜前下区N，N，N’，N’一四甲基乙二胺三碘甲腺原氨酸酪氨酸羟化酶第三军医大学硕士学位论文TheExpressionofId2inAdultRatBrainanditsEffectsontheDevelopmentandDifferentiationofSVZaNeuralStemCellsAb

5、stractItisbelievedthattheanteriorsubvenlricularzone(SVZa)andhippocampusarethemostnumerousaiP纽sofneuralstemcells(NSCs)inadultmammalbrain．neSVZaNSCscontinuouslymigratefromSVZatoolfactorybulb(OB)bythemammal’Swholelife’andformtheroslralmigratorystream(gMS)．SotheSVZaNSCsare

6、therenewingresourceofOBintemeurons．BesideshavingthegeneralcharacteristicsofNSCs，theSVZaNSCshavetheiruniquefeaturesthemselves．．nleSVZaNSCscankeepundifferentiatedallalongin捌MS．AfterarrivingatthecenterofOB。theNSCsthenmigratearoundanddifferentiateintoneuronsandneuralgliace

7、ils．髓edifferentiationofNSCsareaffectednotonlybyinheritfactorssuchasthyroidhormonereceptorsinthecells，butalsobyextracellularsignalssuchasmitogenicfactors(EGF)，thyroidhormone(Ts)，glucocorticoids，retinoicacid(RA)，serum．黜kindofthemechanismitisthatwhytheSVZaNSCskeepundiffer

8、entiatedallalonginRMSisstillunclearnow．弧ecolleaguesinOurlabhadobservedthattranscriptionfactorssuchasBMP2，Mashl，Pax6，W