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1、ACaseofExtremeParadoxicalInsomniaRespondingSelectivelyToElectroconvulsiveTherapyJournalofClinicalSleepMedicine,Vol.4,No.1,200862一例极重度矛盾性失眠患者对电休克疗法的选择性应答病例报告——睡眠医学临床杂志经活动记录仪证实,被诊断抑郁症的48岁妇女的主诉随后被诊断为重度矛盾性失眠。尽管先前认为是安眠药及抗抑郁药物难治的,但经5次电休克治疗后,两种障碍均缓解。关键词:活动记录仪,失眠,睡眠知觉障碍,矛盾性失眠,抑郁症,电休克疗法Severeparadoxi
2、calinsomnia,documentedbyactigraphy,wasthepredominantpresentingcomplaintofa48-year-oldwomansubsequentlydiagnosedwithmajordepression.Bothdisordersremittedfollowingacourseof5electroconvulsivetherapytreatmentsinspiteofbeingpreviouslyrefractorytohypnoticandantidepressantpharmacotherapy.Keywords:A
3、ctigraphy,insomnia,sleepstatemisperception,paradoxicalinsomnia,majordepression,electroconvulsivetherapy,ECT失眠是抑郁症的一项前驱和伴随症状。为达到抑郁症的完全缓解,消除失眠是治疗中的一个重要组成部分。电休克疗法是治疗抑郁症及非典型性抑郁症的一种安全、有效、普遍耐受良好的治疗方法。下面是一例抑郁症伴随严重失眠,经电休克疗法治疗有效的病例。Eliminationofinsomnia,aprecursorandoftenconcurrentsymptomofclinicalde
4、pression,isanimportantcomponentoftreatmentundertakentoachievecompleteremissionofdepression.Electroconvulsivetherapy(ECT)isasafe,effective,generallywell-toleratedtreatmentformajordepression,includingdepressionwithatypicalfeatures.Thefollowingisacaseofmajordepressionpresentingassevereinsomniat
5、hatwasselectivelyresponsivetoECT.病例报告患者为职业女性,48岁,已婚,既往无精神疾病病史。患者因计划自杀入院,她说“因为没有人能指出我的问题在哪”。患者自诉总计“在之前的一个月睡眠35小时”,睡前服用氯硝安定1毫克,羟基安定30毫克,唑吡坦20毫克,或者喹硫平25毫克均无效。REPORTOFCASEA48-year-oldmarried,employedfemalewithnopriorpsychiatrichistorywasadmittedtohospitalwithasuicidalplan“becausenoonecanfigureou
6、twhatiswrongwithme.”Shecomplainedofatotalof“35hourssleepduringthepreviousmonth,”unresponsivetoclonazepam1mg,temazepam30mg,zolpidem20mg,orquetiapine25mgatbedtime.她将此归因于之前因浅静脉炎所行急诊手术静脉造影染色剂过敏性反应使用了三天40毫克泼尼松,以及后续非甾体类抗炎使用引发的胃炎。Sheattributedthistoa3-daycourseofprednisone40mgforanallergicreactiont
7、oradiopaquevenogramdyepriortoemergencysurgeryforsuperficialphlebitis,andgastritisfromsubsequentnonsteroidalantiinflammatoryuse.在医院里,睡前给予米氮平30毫克,连续的规定的羟基安定30毫克,唑吡坦10毫克,扎来普隆10毫克,曲唑酮150毫克,以及每日两次去甲基羟安定15毫克,对改善患者睡眠无效。持续每夜给予米氮平30毫克(作为抗抑郁),经过10天患者诉最低限度地提高