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ID:36761258
大小:1.05 MB
页数:53页
时间:2019-05-14
《参麦注射液对盲肠结扎并穿孔致多器官功能障碍的免疫调节作用》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、广西医科大学硕士学位论文参麦注射液对盲肠结扎并穿孔致多器官功能障碍的免疫调节作用姓名:李蓉申请学位级别:硕士专业:病理生理学指导教师:程建祥2003.4.1参麦注射液对盲肠结扎并穿孔致多器官功能障碍的鱼瘗遢茔作用摘要目的:探讨大鼠盲肠结扎并穿孔引发多器官功能障碍综合征免疫失衡产生机理,并观察参麦注射液对多器官功能障碍综合征的免疫调节作用。方法:用大鼠盲肠结扎并穿孔建立多器官功能障碍综合征模型,于术前5分钟股静脉注入参麦注射液,而后每隔12小时再注射,直到36小时处死。结果:MODS模型组动物肝,。肾功能的生化指标异常,肝、肾、肺、胸腺有病理改变,PM
2、N吞噬率、胸腺指数明显降低,MII升高。外周血TNF—a浓度先升高后下降,但仍高于正常水平;外周血皮质醇浓度先升高后下降,低于正常水平,呈低皮质醇血症。用参麦注射液可提高PMN的吞噬率及改善胸腺指数和MII,减少TNF.Cl过度释放,改善血皮质醇水平。结论:大鼠盲肠结扎并穿孔引发的多器官功能障碍综合征与,过度的应激及炎症失控造成的免疫失衡有关,而参麦注射液对MODS发病过程出现的免疫失衡具有免疫调节作用。关键词:参麦注射液盲肠结扎并穿孔多器官功能障碍综o/。,v,合征免疫失衡、、一,IImmunologictherapyofshenmaiinject
3、iononmultipleorgandysfunctionsydromeinducedbycecalligationandpunctureinratsAbstractObjective:toinvestigatethatimmunologicdissonanceisrelatedtoprogressofthemultipleorgandysfunctionsydromeinducedbycecalligationandpunctureinratsandtostudytheimmunologictherapyofshenmaiinjectiononMO
4、DS.Methods:MODSinducedbyCLRSMlwasadministerdintravenously5minutebeforeoperation,thenrepeatedlyadministersper12hourtill36hafteroperation.Results:Comparewithcontrolgroup36hafterCLP:①thebiochemistrychangesindicatedthatthefunctionofliverandkidneywasdamaged.②pathologicchangeoflung.k
5、idney,lungandthymusweremoresignificantlysevere.③thelevelofTNF—QincreasedrapidlyafterCLPthendecreasemoderatelybutitwasstillhigerthanthelevelofcontrolgroup’.④thelevelofcortisolincreasedrapidlyafterCLPthendecreasedsharplybutitwaslowerthanthelevelofcontrolgroup'.(量)PhagocytosisofPM
6、Nweaked、thymusindexdecreasedandMIIincreasedafterCLP.2Furthermore,pretreatmentwithSMIsignificantlylowedtheexcessivecontentofplasmaTNF—Q,balancedthelevelofthecortisol,improvedtheimmunefunctionoforgan.Conclusion:CLPmayresultinimmunologicdissonanceofMODS.themechanismmaybeinvolvedin
7、malignantstressandoverwhelminginflammation.SMIhaveimmunologictherapyOnMODSagansistCLP.Keyword:Shenmaiinjection;Cecalligationandpuncture;Multipleorgandysfunctionsyndrome;Immunologicdissonance主要缩略语MODS(multipleorgandysfunctionsydrome)多器官功能障碍综合征CLP(Ceealligationandpuncture)盲肠结扎并穿孔
8、SIRS(systemicinflammatoryresponsesyndrome)全身炎症反应综合征CAR
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