烟酸的绿色合成与催化剂研究

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1、浙江工业大学硕士学位论文烟酸的绿色合成与催化剂研究姓名：朱冰春申请学位级别：硕士专业：工业催化指导教师：陈银飞20040501THEGREENSYNTHESIS0FNICOTINICACIDANDSTUDYoFCATALYSTSABSTRACTNicotinicacidiswidelyusedinChemicalindustry，itwasfirstlysynthesizedbytheoxidationofnicotine．Butinindustryitisalwaysderivedfromalkylpyridine，suchas3

2、-picolinc，2-methyl-5一ethylpyridineandquinoline．Thesynthesismethodsarcknownas：liquid—phasedirectoxidationusingHN03and112S04，ammoxidationandoxidationofquinoline．Disadvantagesofaboveprocessesincludepollution，lowproductivity，complexityofprocessstepsandhighexpenseonequipmen

3、ts．Withtherapiddevelopmentofpharmaceuticalandchemicalindustry，thedemandfornicotinicacidincreasesquicklyButtheexistedmethodshaven’tsatisfiedthemarketneeds．Definedbythebackwardtechnology,’ofcountryandtheincreasingpressureonenvironmentalprotection，itisurgenttodevelopnew，e

4、nvironmenlcompatiblesynthesismeanswithlowcapitalinvestment．So，weexperimentedonthissubjectandhadachievedsomepositiveresults．Thethesisconsiststwoparts：SynthesisofNicotinicacidthroughgas—phaseoxidationof3-picoline；SynthesisofNicotinicacidthroughliquid—phaseoxidationof3-·p

5、icoline．Forthegas-phaseoxidationof3-picoline，themaincontentsare：ComparingtheperformanceofcatalystswithdifferentTi02crystalform，anataseisbetter；DesigningandpreparingdifferentV20s／Ti02catalyst，andselectingabetteronebytheyieldofnicotinicacidandthroughcharacterization．Byco

6、mparingandanalyzingalargeamountofexperimentalresults，weconcludedabetterreactionconditionasfollows：(1)anatase’Fi02isthebestcarrierforthecatalyst．(2)whentheV205一containing7Fi02一supposedcatalystwithCr203aspromoterhasa25：74：l(wt)composition，ithasbetterperformance．(3)theoxi

7、dationiscarriedoutatareactiontemperatureof330。C．～’elocityof3-picolinewasO．05h“andthemoleratioofaidwater／3一picolineis100／120／1．Resultsshowedthattheprocessemployedgavehigheryield，betterproductqualityandlesspollution．Thehighestyieldofnicotinicacid(>90％1wasobtained，Forthel

8、iquid—pbaseoxidationof3-picoline。welestedtheactivityofdifferealcatalysts．Furthermorc，theeffectofreactionconditionsony