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ID:36560634
大小:2.54 MB
页数:83页
时间:2019-05-12
《烟酸的绿色合成与催化剂研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、浙江工业大学硕士学位论文烟酸的绿色合成与催化剂研究姓名:朱冰春申请学位级别:硕士专业:工业催化指导教师:陈银飞20040501THEGREENSYNTHESIS0FNICOTINICACIDANDSTUDYoFCATALYSTSABSTRACTNicotinicacidiswidelyusedinChemicalindustry,itwasfirstlysynthesizedbytheoxidationofnicotine.Butinindustryitisalwaysderivedfromalkylpyridine,suchas3
2、-picolinc,2-methyl-5一ethylpyridineandquinoline.Thesynthesismethodsarcknownas:liquid—phasedirectoxidationusingHN03and112S04,ammoxidationandoxidationofquinoline.Disadvantagesofaboveprocessesincludepollution,lowproductivity,complexityofprocessstepsandhighexpenseonequipmen
3、ts.Withtherapiddevelopmentofpharmaceuticalandchemicalindustry,thedemandfornicotinicacidincreasesquicklyButtheexistedmethodshaven’tsatisfiedthemarketneeds.Definedbythebackwardtechnology,’ofcountryandtheincreasingpressureonenvironmentalprotection,itisurgenttodevelopnew,e
4、nvironmenlcompatiblesynthesismeanswithlowcapitalinvestment.So,weexperimentedonthissubjectandhadachievedsomepositiveresults.Thethesisconsiststwoparts:SynthesisofNicotinicacidthroughgas—phaseoxidationof3-picoline;SynthesisofNicotinicacidthroughliquid—phaseoxidationof3-·p
5、icoline.Forthegas-phaseoxidationof3-picoline,themaincontentsare:ComparingtheperformanceofcatalystswithdifferentTi02crystalform,anataseisbetter;DesigningandpreparingdifferentV20s/Ti02catalyst,andselectingabetteronebytheyieldofnicotinicacidandthroughcharacterization.Byco
6、mparingandanalyzingalargeamountofexperimentalresults,weconcludedabetterreactionconditionasfollows:(1)anatase’Fi02isthebestcarrierforthecatalyst.(2)whentheV205一containing7Fi02一supposedcatalystwithCr203aspromoterhasa25:74:l(wt)composition,ithasbetterperformance.(3)theoxi
7、dationiscarriedoutatareactiontemperatureof330。C.~’elocityof3-picolinewasO.05h“andthemoleratioofaidwater/3一picolineis100/120/1.Resultsshowedthattheprocessemployedgavehigheryield,betterproductqualityandlesspollution.Thehighestyieldofnicotinicacid(>90%1wasobtained,Forthel
8、iquid—pbaseoxidationof3-picoline。welestedtheactivityofdifferealcatalysts.Furthermorc,theeffectofreactionconditionsony
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