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ID:36557693
大小:1.26 MB
页数:42页
时间:2019-05-12
《血小板衍生生长因子β在兔蛛网膜下腔出血后脑血管痉挛模型中的表达》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、苏州大学硕士学位论文血小板衍生生长因子-β在兔蛛网膜下腔出血后脑血管痉挛模型中的表达姓名:崔红凯申请学位级别:硕士专业:影像医学与核医学指导教师:刘一之20070501血小扳衍生生长园子-B在兔蛛网膜下腔出血后脑血管痉挛模型中的表达英文摘要TheExpressionofPlatelet—DerivedGrowthFactor-pinCerebralVasospasmafterSubarachnoidHemorrhagewithaRabbitEndovascularPunctureModelAbstractObjective:Tostudytheexpressi
2、onandtimeCOHI'Seofplatelet-derivedgrowthfactor-pincerebralvasospasmaftersubaranhnoidhemorrhagewitharabbitendovascularpuncturemodel,andtodiscussthesignificance.MaterialandMethods:CerebralvasospasmmodelwasproducedafterSAHbYendovasculaxpuncturemethod.35NewZealandwhiterabbitswithhealtha
3、ndclean.TheSAIlgroupswel'edividedintoSCVerlgroups(including3h、12h、ld、2d、3d、7d、14d),everygrouphasfiverabbits.Allrabbitsweretakenveinbloodbyeachtime.Thes哪mlevelsofPDGF—BB、】l舢detectedbymeansofe咀Zyrflelinkedimmunosorbentassay(ELISA).Afterperfusion-fixed,sectionedsliceswereexaminedbyligh
4、tmicroscopytomea吼I聆luminalnarrowingandwallthicknessofposteriorcommunicatingarteryandbasfl盯artery.TheimmunohistochemistrytechniqueWasusedtostudyexpressofplatelet-derivedgrowthfactor-pinSmoothmusclecellwithbasilararteryandposteriorcommunicatingartery.Result:Amongall,brainsof45rabbits(
5、including35rabbitswithsubarachnoidhemorrhage)wereharvested.Compareingwithnormalgroupandnonoperationgroup,posteriorcommunicatingarteryandbasfl盯arteryshowedluminalnarrowingandwallthickness.EnhancedexpressionofPDGF—DproteinatCVSWass∞nat3h,anditsmarkedup—regulationwasnotedat3-7days,andt
6、hentheexpressionbecamedecreasedbutitremainedabovethecontrollevelsstill14daysafI盯cerebralvasospasm.Conclusion:Wedemonstratethatthismodelshowesbiphasicpatternstotheluminalnarrowing:acllteanddelayedconstrictionphase.TheexpressionofPDGF—p¨垒!:堡堑竺生苎里王:望垄墨生塑堕!些坐些生堕皇竺垄皇垡型主塑墨垄茎苎塑塞obviousdsea
7、ndthe陀glllafchangeintimec.,ourseincerebralvasospasmaftersubarachnoidhemorrhage.ItisimportantsignificanceinthecourseofoccurrenceanddevelopmentpathologyafI盯cerebralvasospasm.KeyWords:cerebralvasospasm;rabbit;subarachnoidhemorrhage;platelet-dedvedgrowthfactor-pIUWrittenby:CuiHongKaiSup
8、ervisedby:LiuYiZhi血
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