轮状病毒肠炎导致肠道菌群失调临床分析

《轮状病毒肠炎导致肠道菌群失调临床分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、轮状病毒肠炎导致肠道菌群失调临床分析作者：张翊，赖志光，黄仰銮，朱霭红【摘要】目的探讨婴幼儿轮状病毒肠炎与肠道菌群紊乱的关系，为临床诊断和合理治疗提供重要意义。方法对广州市越秀区儿童医院2008年9月至2009年2月住院的婴幼儿腹泻病的粪便标本进行轮状病毒的检测和大便细菌培养及药敏试验。结果本调查在346例婴幼儿中测得轮状病毒(RV)阳性共120例(34.7%)，其中6~12月龄婴儿发病率占44.2%。在RV阳性组中检测出条件致病菌菌株12株(10.0%);在RV阴性组中检测出9株(3.98%)，阳性组显著高

2、于阴性组(χ2=4.979,P<0.05)。其中在以上的21株菌株中1岁以内小儿发现14例,占66.6%。对该21株肠杆菌科病原菌的药敏结果显示，对大部分常用抗生素均有较严重的耐药。结论RV阳性婴幼儿腹泻较RV阴性婴幼儿更易发生肠道菌群紊乱并发条件致病菌感染，且以1岁以内消化道屏障防御功能发育未完善的小儿多发。为不疏忽内源性条件致病菌引起的婴幼儿腹泻，建议均要及时进行粪便培养，根据药敏试验合理选用抗生素指导临床用药。【关键词】婴幼儿腹泻;轮状病毒;条件致病菌;肠道菌群紊乱　　[Abstract]Obje

3、ctiveToinvestigaterelationshipbetweentherotavirusgastroenteritisininfantsandthe8intestinalfloradisorder,forclinicaldiagnosisandrationaltherapyofsignificance.MethodsTocheckthehospitalizedinfantsandyoungchildrendiarrhearotavirusstoolsamples，stoolbacterialcult

4、ureanddrugsensitivitytestinYuexiuDistrictGuangzhouChildren'sHospitalfromSeptember2008toFebruary2009.ResultThissurveywasfrom346casesofinfantsandyoungchildrendetectedrotavirus(RV)positiveforatotalof120cases(34.7%),ofwhich6to12monthsofageaccountedfor44.2%ofinf

5、antmorbidity.RV-positivegroupisdetectedopportunisticpathogenicstrainsin12(10.0%);intheRV-negativepatientsdetected9(3.98%),positivegroupwassignificantlyhigherthanthenegativegroup(χ2=4.979,P<0.05)。Amongthesewhole21strainswithin1yearofagewasfoundin14cases,a

6、ccountingfor66.6%.Ofthe21enterobacteriaceaepathogensusceptibilityresultsshowedthatthemajorityofcommonlyusedantibioticsaremoreseriousresistance.ConclusionRV-positiveinfantsandchildrenwithdiarrheaininfantsandyoungchildrenmoresusceptibletointestinalfloradisord

7、erandcomplicatedinfectionbyopportunisticpathogenthanRV-negative,andmoremultipleforthechildrenwithinayearwhosedevelopmentofthedigestivetractbarrierdefensefunctionisnotyetperfect.Theconditions8fornon-negligenceofendogenouspathogenicbacteriacauseddiarrheaininf

8、ants,itisrecommendedstoolcultureshavetobeinatimelymanner,accordingtoareasonableselectionofantibioticsusceptibilitytestingtoguideclinicalpractice.　　[Keywords]infantilediarrhea;rotavirus;opportunisticpat