volumetric automatic breast density assessment in an …：容量自动乳腺密度评估一…

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1、AutomaticVolumetricBreastDensityAssessmentintheeXtensibleImagingPlatformRachelEmbreeandChristinaSilleryDavidChannin,MD,AdvisorInCooperationwithAlexShnayder,PatMongkolwat,RayWuOverviewIntroductionMaterialandMethodsResultsDiscussionConclusionIntroductionWhatisBre

2、astDensity?Thebreastiscomposedoffibroglandulartissueembeddedinabackgroundoffattytissue.Theamountoffibroglandulartissueandfatvariesamongwomen.Breastcancerarisesinthisfibroglandulartissue.Mammographyisprojectionradiographyofthebreast.Inmammograms,densefibroglandu

3、lartissueattenuatesmoreradiationthandoesfat.Breastdensityreferstotheappearanceofthisfibroglandulartissueinamammogram[5]BreastDensityPositivelycorrelatedwithbreastcancerFourtosixtimesgreaterriskofbreastcancerforwomenwithgreaterthan60%densetissue[1]Breastdensitya

4、sariskfactoraccountsforasmanyas30%ofbreastcancercases[1]Canbechangedbyhormonal,dietaryandotherinterventionsAssessmentofBreastDensityinMammogramsSubjectiveVisualAssessmentbyRadiologists(Mandatory)Scorethebreastona4-pointscaleintheBreastImaging-ReportingandDataSy

5、stem(BIRADS),basedonpatternsdevelopedbyWolfe[5]ManualImageProcessingTechniques(forresearch)PlanimetryInteractiveThresholdingPreviousApproachesInteractiveThresholdingGoalCreateabreastdensityassessmentprogramthatis…AutomatedVolumetricAccurateIntheeXtensibleImagin

6、gPlatform(XIP)MaterialandMethodsWhatisXIP?eXtensibleImagingPlatformFundedbyNIH,NCICancerBioinformaticsGrid(caBIG)ProgramAprogramtosharedata,informaticstools,technologiesandinfrastructurebetweenthefundedComprehensiveCancerCentersacrossthenationOpenSource,OpenSta

7、ndards,OpenArchitecturePlatformfordevelopmentofmedicalimageprocessingandanalysisapplicationsforresearchandclinicalpurposes.WillsupporttheDICOMApplicationHostingstandardtofacilitatetransportabilityofXIPapplicationsXIPBuilderVisualProgrammingEnvironmentfordevelop

8、ingimagingapplications;basedonOpenInventor.Containsmodules(lots!)thatcanbeassembledtoperformsophisticatedtasks.IncludesvTK–TheVisualizationToolkit(NIH)iTK–TheInsightToolkitf