毕业论文--肿瘤标志物联合检测在胃癌诊断中的应用价值

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1、河南科技大学毕业论文肿瘤标志物联合检测在胃癌诊断中的应用价值摘要：目的：研究血清癌胚抗原（CEA）、糖类抗原199、（CA-199)、糖类抗原72-4（CA72-4）、糖类抗原（CA50)联合检测在胃癌诊治中的临床价值，以筛选理想的血清肿瘤标志物组合，提高临床诊断胃癌的灵敏度、诊断率。方法：应用放射免疫分析（RIA）法和化学发光免疫分析法测定100例胃癌患者和46例非胃癌患者的血清中CEA、CA199、CA724、CA50四种肿瘤标志物的含量，并分析单个肿瘤标志物和五种标志物联检对胃癌的敏感性和特

2、异性结果：胃癌组CEA、CA199、CA724、CA50水平明显高于非胃癌组(P<0．05)、胃癌患者血清水平，CEA、CA199、CA724、CA50阳性表达率分别为52.00％、45.00％、47.00％、34.00％。联合检测阳性率为CEA+CA199=79%、CEA+CA724=76%、CEA+CA50=63%CA199+CA724=58%CA199+CA50=50%CA724+CA50=51%、CEA+CA199+CA724=88%、CEA+CA724+CA50=86%、CEA+CA19

3、9+CA50=83%、CA199+CA724+CA50=80%CEA+CA199+CA724+CA50=92%。两者联合检测较单一指标阳性率高，三者联合检测普遍较两者检测阳性率高，四者联合检测普遍较三者联合检测阳性率高(P

4、4(CA72—4)四种血清肿瘤标志物在胃癌诊断中具有较高的辅助诊断价值，四项标志物联合检测有助于提高胃癌诊断的灵敏度及预后判断。关键词：胃癌，肿瘤标志物，联合检测，诊断49河南科技大学毕业论文THEDIAGNOSTICVALUEOFCOMBINEDDETECTIONWITHFOURTUMORMAKERFORGASTRICCANCERABSTRACTObjective:ToresearchtheclinicalsignificanceofserumtumormarkersCEA、CA199、CA72

5、4、CA50inthediagnosisofgastriccancer,tofiltertheidealserumtumormarkerscombination.SOastoimprovethesensitivityanddiagnosisratioforgastriccarcinoma．Methods:TheserumconcentrationoftumormakersCEA,CA199,CA724,CA50intheserumof100patientswithgastriccancerand4

6、6healthyindividualsweremeasuredbyradioimmunoassay(RIA)andelectrochemiluminescencemethodMeanwhile，analyzingthedifferenceofasingletumormarkersandthecombineddetectionoffourtumormarkersinsensitivityandspecificityforthegastriccancer．Results:Theserumlevelso

7、fCEA,CA125,CA199,CA724inpatientswithgastriccancerwereobviouslyhigherthanthoseinthecontrolgroupIthasstatisticalsignificance(P<0．05).TherespectivepositiveexpressionratesofCEA,CA199,CA724,CA50insumerare52.00％、45.00％、47.00％、34.00％．Thepositiveratesoftheuni

8、tetestofindexareasfollows,CEA+CA199is79.00%、CEA+CA724is76.00%、CEA+CA50is63.00%CA199+CA724is58.00%CA199+CA50is50.00%CA724+CA50is51.00%、CEA+CA199+CA724is88.00%、CEA+CA724+CA50is86.00%、CEA+CA199+CA50is83.00%、CA199+CA724+CA50is80.00%CEA+CA199+CA724