参芎葡萄糖注射液对兔颈动脉球囊损伤后血管内膜增生的作用

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1、授予单位代码10089学号或申请号13271HebeiMedicalUniversity硕士学位论文在职科学学位参芎葡萄糖注射液对兔颈动脉球囊损伤后血管内膜增生的作用学位申请人：石秀彩导师：信栓力教授专业：内科学二级学院：邯郸市第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试

2、验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名一导师签章：二级学院领导盖章：yr年t月巧日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要·············································································1英

3、文摘要·············································································3英文缩写·············································································6研究论文参芎葡萄糖注射液对兔颈动脉球囊损伤后血管内膜增生的作用前言·····································································

4、········7材料与方法····································································8结果·············································································13附图·············································································15附表··················

5、···························································22讨论·············································································24结论·············································································25参考文献······································

6、·································25综述中药抑制内膜增生机制的研究进展·····································28致谢···················································································33个人简历·············································································34中文摘要

7、参芎葡萄糖注射液对兔颈动脉球囊损伤后血管内膜增生的作用摘要目的：目前我国介入治疗冠心病应用广泛，但其术后再狭窄影响了介入治疗的远期疗效。虽然辛伐他汀在临床上的应用减少了介入术后再狭窄的发生率，但仍有必要探索更多的药物来干预介入术后再狭窄。血管内膜增生为冠脉粥样硬化及介入术后血管再狭窄的重要特征，可能的机制包括：内皮损伤及功能障碍；炎症反应；血小板聚集，血管平滑肌细胞增殖、迁徙等。研究表明参芎葡萄糖具有改善血液流变学、脂质代谢异常，以及降低炎症因子等作用。本实验建立了在高脂饮食条件下、球囊损伤的新西兰兔颈动脉血管内膜增生模型，

8、旨在观察参芎葡萄糖注射液对兔颈动脉内膜增生形成的影响及分析其可能的机制，为进一步研究防止血管介入术后再狭窄的药物治疗提供有意义的实验室依据。方法：选取4月龄健康雄性新西兰兔，分为：1对照（C）组，仅给予高脂饮食，无球囊损伤，无药物干预；2手术（O）组，给予高脂饮食，并球囊损伤；3辛伐他汀（