fbxw7参与肝癌侵袭和转移的机制研究

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1、分类号R735.7UDC616-006密级公开Fbxw7参与肝癌侵袭和转移的机制研究王兴培养类别全日制学位类型学术学位一级学科(专业类)临床医学二级学科(专业)外科学（普外）研究方向肝癌的发生机制、肝癌干细胞指导教师窦科峰教授（主任医师）培养单位西京医院肝胆胰脾外科二O一五年五月第四军医大学博士学位论文目录缩略语表·······························································································1中

2、文摘要·······························································································3英文摘要·······························································································6前言······················································

3、········································10文献回顾······························································································12正文······························································································30第一部分Fbxw7在肝细胞肝癌

4、中的表达及其临床意义································30引言·······························································································301材料····························································································302方法············

5、················································································323结果····························································································384讨论·········································································

6、···················43第二部分构建Fbxw7干扰、过表达慢病毒载体并稳转肝癌细胞系·················46引言·······························································································461材料···················································································

7、·········462方法····························································································503结果····························································································564讨论···············································

8、·············································59第三部分Fbxw7对肝癌细胞系侵袭和转移的影响·······································61引言·······························································································611材料··