自发性高血压大鼠慢性脑损害以及药物的影响

《自发性高血压大鼠慢性脑损害以及药物的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20122130对於(E搿大迳HebeiMedicalUniversity科学学位自发性高血压大鼠慢性脑损害以及药物的影响研究生：罗长均导师：胡福广教授专业：外科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报

2、的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：T^ir年j月>曰目录中文摘要·············································································1英文摘要················

3、·····························································4英文缩写·············································································9研究论文自发性高血压大鼠慢性脑损害以及药物的影响前言·············································································11材料与方法············

4、························································12结果·············································································21附图·············································································24附表············································

5、·································26讨论·············································································28结论·············································································34参考文献·································································

6、······34综述高血压和慢性脑损害·····················································39致谢···················································································47个人简历·············································································48中文摘要自发性高血压大鼠慢性脑损害以及药物的

7、影响摘要随着现代社会的发展和人们快节奏的生活方式，高血压等慢性疾病呈现出多发、常见、低龄化的态势，人群中高血压病的存在更加普遍。高血压病严重危害人类的健康，它是多种心、脑血管疾病的重要病因和危险因素，长期持续的高血压可对血管产生严重的影响，造成血管损害，病理学上表现为内膜弹性纤维增生，中膜平滑肌细胞增生、肥大，并在一定程度上伴有胶原纤维和弹性纤维的增生，其结果就是血管壁增厚而造成血管腔狭窄，血管弹性减弱，如此又可进一步使血压情况恶化。脑部血管因为管腔狭窄会导致脑部供血减弱，进而使脑部缺氧，长此以往会改变脑组织的结构和损害其功能

8、，发生神经生理学上的改变。当高血压持续时，机体的氧化应激反应可增强，大量的实验研究表明高血压与氧化应激之间存在紧密的联系。正常时，活性氧簇（ROS）保持在较低水平，高血压会改变这种常态，使活性氧簇显著增多，打破机体氧化和抗氧化之间维持的平衡，自由基的生成增多，心脏、肾脏、脑等