血管性痴呆与血清尿酸水平的相关性研究

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1、授予单位代码10089m学号或申请号13235HebeiMedicalUniversity硕士学位论文在职科学学位血管性痴呆与血清尿酸水平的相关性研究学位申请人：李静导师：张国华教授专业：神经病学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数

2、据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。研究生签名：卞$<导师签章：二级学院领导盖章：J知丄年彡月f曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人已发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：^导师签章：dSlf^^•〈月

3、曰目录中文摘要··························································

4、······················1英文摘要················································································4英文缩写················································································8研究论文血管性痴呆与血清尿酸水平的相关性研究前言············································

5、···································9资料与方法····································································10结果·············································································12附图···································································

6、··········13附表·············································································17讨论·············································································19结论·············································································24参考文献··

7、·····································································25综述血管性痴呆发生发展的相关因素…………………………………..27致谢····················································································36个人简历·································································

8、·············37中文摘要血管性痴呆与血清尿酸水平的相关性研究摘要目的:血管性痴呆（VaD）是我国发病率较高的一种痴呆类型。在老年性痴呆中，发病率仅仅低于Alzheimer病（AD）。VaD发病的基础疾病多是脑血管病，当病变影响到与认知功能等有关的高级功能区时，便可能导致认知障碍，逐渐或迅速发生痴呆。VaD每年的发病率为5-9/1000人。其中血管性痴呆患者可占到痴呆总人数五分之一左右；同时患有Alzheimer病和血管性痴呆（VaD）者可占到十分之一至五分之一。一旦患有血管性痴呆将给社会及家庭带来沉重的

9、负担，而且患者本人的生活质量将明显下降。尽管现代医疗水平已取得了突飞猛进的发展，对于疑难杂症的攻克亦取得了举世瞩目的成就，但仍有不治之症存在，例如血管性痴呆一旦确诊，目前尚无根治办法，只是停留在改善或延缓认知功能症状的治疗，因而，全面了解并预防血管性痴呆（VaD）的发生迫在眉睫。经过医学者与患者的共同努力，对于糖尿病、高脂血症、高血压、烟、酒以