凋亡细胞对巨噬细胞il-12家族细胞因子调控的研究

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1、授予单位代码10089学号或申请号13491HebeiMedicalUniversity硕士学位论文在职科学学位凋亡细胞对巨噬细胞IL-12家族细胞因子调控的研究学位申请人：刘冰慧导师：钱雪松副教授专业：免疫学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北

2、医科大学所有。否则，承担相应法律责任。.研究生签名师签“二级学院领导盖章：，y/Jr年r月vi�曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：；g�导师签章：破、hMt"年t月？上日目录中文摘要·····························································································

3、···········1英文摘要········································································································4英文缩写········································································································8研究论文凋亡细胞对巨噬细胞IL-12家族细胞因子调控的研究前言························

4、··············································································9材料与方法··························································································10结果······································································································23附图·

5、·····································································································26讨论······································································································34结论··········································································

6、····························36参考文献······························································································37综述凋亡细胞清除的基本生物学和治疗潜力·······································39致谢·····························································································

7、·················50个人简历······································································································51中文摘要凋亡细胞对巨噬细胞IL-12家族细胞因子调控的研究摘要目的：机体通过吞噬作用清除凋亡细胞（apoptoticcell，apo），避免凋亡细胞的具有潜在细胞毒性、免疫原性或致炎性的坏死成分暴露在周围环境中引发自身免疫反应和炎症反应，这是机体一种重要的防御功能。因此快速有效清除体内的凋亡细胞对人体正常生长发育和

8、维持内环境