急性百草枯中毒患者早期预后指标的临床分析

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1、授予单位代码学号或申请号13452对妗€钭大迳HebeiMedicalUniversity硕士学位论文在职科学学位急性百草枯中毒患者早期预后指标的临床分析学位申请人：侯运辉导师：苏建玲副教授田英平教授专业：急诊医学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申

2、报的专利等知识产权均归河北医科大学所有。否则,承担相应法律责任。研究生签名hl导师签章对二级学院领导盖章：上o(5年5月丨1日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：彳导师签章：Mfi年t月日目录中文摘要··········································································

3、···1英文摘要·············································································4英文缩写·············································································8研究论文急性百草枯中毒患者早期预后指标的临床分析前言·············································································9资

4、料与方法····································································10结果·············································································12附图·············································································16附表···································

5、··········································17讨论·············································································19结论·············································································26参考文献·······························································

6、········26综述百草枯中毒预后因素研究现状·········································29致谢···················································································42个人简历·············································································43中文摘要急性百草枯中毒患者早期预后指标的临床分析摘要目的：目前临床上大

7、量研究集中在百草枯中毒的治疗，早期预后指标的研究相对较少。预后指标的研究不仅有利于早期临床干预，同时对于患者病情发展的判断及治疗方案的确定有着重要的意义。本研究通过对急性百草枯中毒患者口服剂量、早期血药浓度、24小时内最差APACHEⅡ评分、24小时内最差氢离子浓度指数(PH值)、24小时内最差碳酸氢根离子(HCO3-)、24小时内最差白细胞计数(WBC)、24小时内最差血钾(K+)、24小时内最差血肌酐(CR)等指标与百草枯中毒患者预后进行相关性分析，为临床评估患者病情严重程度、判断预后及确定治疗方案提供参考。方法：1收集沧州市人民医院2

8、009年1月至2013年08月期间收治的急性百草枯中毒患者资料。2筛选口服中毒患者中，入院即留取血标本送北京307毒物检测中心，采用日本岛津公司LC-20AT型高效液相色谱仪，配