右美托咪定辅助镇静对全身麻醉患者术后睡眠功能的影响

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1、授予单位代码—10089学号或申请号13636HebeiMedicalUniversity硕士学位论文在职科学学位右美托咪定辅助镇静对全身麻醉患者术后睡眠功能的影响学位申请人：姜博导师：宋铁鹰教授专业：麻醉学二级学院：石家庄市第一医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。

2、否则，承担相应法律责任。•./

3、···············································3英文缩写·············································································6研究论文右美托咪定辅助镇静对全身麻醉患者术后睡眠功能的影响前言·············································································7资料与方法··················································

4、··················7结果·············································································11附表·············································································12讨论·············································································13结论······························

5、···············································17参考文献·······································································18综述睡眠障碍的研究进展·····················································24致谢···················································································34个人简历···········

6、··································································35中文摘要右美托咪定辅助镇静对全身麻醉患者术后睡眠功能的影响摘要目的：评估右美托咪定辅助镇静对全身麻醉患者术后睡眠功能的影响。方法：2012年12月至2014年12月在石家庄市第一医院行择期全身麻醉胃癌根治术手术的患者60例。入选标准：年龄40~60岁，ASA为I～II级，经过医院伦理委员会审核通过，患者及其家属知情同意后。采用随机数字表法分为3组（n=20）：七氟醚维持组(S组)、丙泊酚静脉维持组（P组）和丙泊酚复合右美托咪定静脉维持组（PD组）。

7、麻醉过程：所有患者术前常规给予阿托品0.5mg，苯巴比妥钠0.1g肌注，入室后开放静脉通道，常规监测心电图(ECG)、血氧饱和度(SpO2)、行桡动脉穿刺，有创动脉内血压监测(ABP)、中心静脉穿刺，中心静脉压监测（CVP）、脑电双频指数(BIS)等监测。麻醉诱导：依次静注咪达唑仑：0.1~0.2mg/kg，舒芬太尼：0.6μg/kg，丙泊酚0.5~1mg/kg，罗库溴铵0.6mg/kg，经口明视下气管插管，麻醉诱导插管过程中，维持有创动脉血压和心率波动不超过基础值±