乌司他丁联合crrt在icu感染性休克患者应用效果评价

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1、授予单位代码10089学号或申请号13265HebeiMedicalUniversity硕士学位论文在职科学学位乌司他丁联合CRRT在ICU感染性休克患者应用效果评价学位申请人：亢宏山导师：赵鹤龄教授f业：急诊医学二级学院：河北省人民医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北

2、医科大学所有。否则，承担相应法律责任。一研究生签名导师签章：‘二级学院领导盖章w年%V赞c.¥二河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。r年夕6月外日目录中文摘要·············································································1英文摘要···································

3、··········································2英文缩写·············································································3研究论文乌司他丁联合CRRT在ICU感染中毒性休克患者应用效果评价前言·············································································6材料与方法··············································

4、······················7结果·············································································9附图·············································································10附表·············································································16讨论······················

5、·······················································19结论·············································································25参考文献·······································································26综述严重脓毒症并发AKI诊治进展······································29致谢················

6、···································································36个人简历·············································································37中文摘要乌司他丁联合CRRT在ICU感染性休克患者应用效果评价摘要背景：目前在ICU感染是诱发患者发生全身炎症反应的主要原因，是脓毒症发展到一定阶段最具威胁的并发症，特别是感染性休克，具有较高的病死率，严重威胁民众的身体健康，已经成为导致重症患者死亡的主要原因。虽然近年来新

7、的治疗方法不断出现，但是死亡率并没有明显下降，感染患者发生感染性休克与感染后炎性介质的过度释放有关，促炎介质的过度释放抑制了机体的免疫功能，所以抑制炎症介质的释放及炎症介质的有效清除，阻断其发展为感染性休克是严重脓毒症治疗成功与否的关键。CRRT能够有效清除脓毒症患者体内的炎症介质，调节白细胞的反应性，从而减轻炎症反应；乌司他丁能够抑制体内多种酶的活性，从而抑制感染性休克患者炎症介质的过度释放，本研究通过观察乌司他丁联合CRRT治疗感染性休克的临床效果，并且探讨其可能的作用机制，为乌司他丁联合CRRT治疗感染性休克提供理论依据