tl1a在结肠炎相关结直肠癌动物模型中作用的初步探讨

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1、授予单位代码10089学号或申请号20122058HebeiMedicalUniversity硕士学位论文科学学位TL1A在结肠炎相关结直肠癌动物模型中作用的初步探讨研究生：王静导师：张晓岚教授专业:内科学二级学院:第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验

2、样料r原举数据、申报的专利等知识产权均归河北医科大学所有。否则，承彳旦相应法彳拿责任。/,‘‘哦丨

3、“V、丄研究生签名导师签章二级学院领号；盖章：、V赠年二；月玛日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要····························································

4、·············································1英文摘要·········································································································4英文缩写····································································································

5、·····7研究论文TL1A在结肠炎相关结直肠癌动物模型中作用的初步探讨前言·········································································································8材料与方法·····························································································9结果···············

6、·························································································21附图········································································································25讨论···························································

7、·············································34结论········································································································37参考文献································································································38综述N

8、F-κB和STAT3信号通路在结肠炎相关结直肠癌中的作用··········40致谢················································································································49个人简历····································································································

9、····50中文摘要TL1A在结肠炎相关结直肠癌动物模型中作用的初步探讨摘要近年来，炎症与肿瘤的关系迅速成为研究领域的热点，大量临床和基础研究均表明，炎症与多种肿瘤的发生、发展有关。结肠炎相关结直肠癌（colitis-associatedcancer,CAC）是一种与炎症性肠病（inflammationboweldisease,IBD）密切相关的结直肠癌，占