swiprosin-1在血脑屏障通透性调节中的作用及机制研究

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1、目录摘要.........................................................................................................................-1-Abstract.....................................................................................................................-6-Abbreviations......

2、....................................................................................................-12-前言.......................................................................................................................-13-第一章...........................................

3、..........................................................................-16-一材料和试剂...................................................................................................-16-二实验方法...................................................................................

4、....................-21-（一）动物模型制作......................................................................................-21-（二）伊文思蓝检测血脑屏障功能破坏......................................................-25-（三）免疫组织化学....................................................................

5、..................-27-（四）大鼠脑微血管内皮细胞原代培养......................................................-28-（五）细胞氧糖剥夺实验..............................................................................-30-（六）免疫组织（细胞）荧光染色..............................................................-33-（七）统

6、计学分析..........................................................................................-34-三结果...............................................................................................................-35-（一）Swiprosin-1的表达水平及定位分布...................................

7、..............-35-（二）缺血性脑卒中模型中swiprosin-1表达情况.....................................-38-（三）LPS模型中swiprosin-1表达情况.....................................................-42-（四）冻伤模型中swiprosin-1表达情况.....................................................-44-第二章Swiprosin-1对血脑屏障通透性调节作用及机

8、制探讨..........................-48-一、材料和试剂...................................