mir-200c通过靶向znf217与zeb1抑制tgf-β信号并调控乳腺癌trastuzumab耐药与转移

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1、分类号R392.12UDC616-006密级公开MiR-200c通过靶向ZNF217与ZEB1抑制TGF-β信号并调控乳腺癌trastuzumab耐药与转移白文栋培养类别全日制学位类型学术学位一级学科(专业类)基础医学二级学科(专业)免疫学研究方向肿瘤与病毒感染的分子免疫指导教师杨安钢教授培养单位基础医学院免疫学教研室二O一五年五月第四军医大学博士学位论文目录缩略语表··································································

2、····························1中文摘要······························································································3英文摘要······························································································7前言······················

3、·······································································12文献回顾·····························································································14正文·············································································

4、················32实验一Trastuzumab耐药乳腺癌恶性表型鉴定及TGF-β信号的调控作用···········321材料···························································································332方法···················································································

5、········343结果···························································································424讨论···························································································48实验二MiR-200c调控乳腺癌trastuzumab耐药、转移及TGF-β信号·········

6、·········521材料···························································································532方法···························································································543结果·············································

7、··············································604讨论···························································································72实验三MiR-200c调控乳腺癌trastuzumab耐药、转移及TGF-β信号的分子机制···741材料······················································

8、·····································742方法···························································································763结果···························································································874讨论·········