氯吡格雷不同服药时间对不稳定型心绞痛患者血小板功能的影响

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1、授予单位代码10089学号或申请号20122018HebeiMedicalUniversity硕士学位论文氯吡格雷不同服药时间对不稳定型心绞痛患者血小板功能的影响研究生：赵秋芳导师：郝玉明教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、

2、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。f•'•‘‘^、，«}J»级学院领导盖章年」.月.日/河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研允生签名：导师签早目录中文摘要·············································································1英文

3、摘要·············································································4英文缩写·············································································8研究论文氯吡格雷不同服药时间对不稳定型心绞痛患者血小板功能的影响前言·······································································

4、······10材料与方法····································································10结果·············································································13附图·············································································15附表····················

5、·························································16讨论·············································································18结论·············································································25参考文献··········································

6、·····························26综述抗血小板药物的研究进展···············································32致谢···················································································47个人简历·············································································48中文摘要

7、氯吡格雷不同服药时间对不稳定型心绞痛患者血小板功能的影响摘要目的：目前冠状动脉粥样硬化性心脏病是人类重要的致死性疾病之一，而动脉粥样硬化，斑块破裂以及血栓形成是其重要的病理过程。血小板作为血栓的主要组成成份，在血栓形成中，特别是在动脉血栓和微血管血栓形成中起着关键作用。因此，临床上抗血小板药物的应用成为该类疾病预防和治疗的主要手段，并取得了显著疗效。目前抗血小板药物种类繁多，包括环氧化物酶抑制剂，P2Y12受体抑制剂，GPⅡb/Ⅲa受体拮抗剂等等；其中P2Y12受体抑制剂包括普拉格雷、替格瑞洛、氯吡格雷等，氯吡格雷是目前常用的抗

8、血小板治疗药物。阿司匹林联合氯吡格雷的双联抗血小板治疗已经成为急性冠状动脉综合征治疗的基石。在对于阿司匹林服药时间的研究方面，有关研究人员进行的随机交叉设计研究表明，阿司匹林晚上服药比早晨服药能够更为显著的抑制血小板聚集力，因为血小板在晨起的时候活性更高，晚上服