邢台地区丙型肝炎病毒基因型分布及持续病毒学免疫应答影响因素分析

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1、授予单位代码10089学号或申请号HebeiMedicalUniversity硕士学位论文在职科学学位邢台地区丙型肝炎病毒基因型分布及持续病毒学免疫应答影响因素分析作者姓名：张彦芳导师：赵宏儒教授专业：病原生物学二级学院：河北省疾病预防控制中心2015年03月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,

2、第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名导师签章〒级学院领导盖章：I年〈月7曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章：1^ir年<月/曰目录中文摘要·····································

3、········································1英文摘要·············································································4英文缩写·············································································8研究论文邢台地区丙型肝炎病毒基因型分布及持续病毒学免疫应答影响因素分析前言·············

4、································································9材料与方法····································································11结果·············································································17附图································

5、·············································20附表·············································································22讨论·············································································26结论············································

6、·································28参考文献·······································································28综述丙型肝炎的相关知识·······················································31致谢·········································································

7、··········40个人简历·············································································41中文摘要邢台地区丙型肝炎病毒基因型分布及持续病毒学免疫应答影响因素分析摘要目的：研究分析邢台地区丙型肝炎患者病毒基因型分布特征，以及与疾病进展、严重程度、获得持续病毒学免疫应答（SVR）的关系，探讨持续病毒学免疫应答影响因素，为判断其预后及提供针对性的个体化治疗提供依据。方法：1资料来源2010年12月至2014年12

8、月，邢台市人民医院初诊治疗的丙型肝炎患者231例，诊断标准依据中华医学会肝病学分会，传染病与寄生虫病学分会于2004年3月制定发布的《丙型肝炎防治指南》。2数据来源2.1数据采集本论文分析探讨了231例丙型肝炎患者的实验室指标，包括丙肝基因分型，丙肝RNA载量，SVR,ALT，AST，WBC，同时整理相关病例基础性资料。2.2指标检测2.2.1基因分型HCV基因分型测定试剂为泰普生物科学有限公司提供,采用PCR-荧光探针法，仪