Bex2 is Critical for Migration and Invasion.pdf

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1、JMolNeurosci(2013)50:78–87DOI10.1007/s12031-012-9864-8Bex2isCriticalforMigrationandInvasioninMalignantGliomaCellsXiupingZhou&XuebinXu&QingmingMeng&JinxiaHu&TongleZhi&QiongShi&RutongYuReceived:8June2012/Accepted:23July2012/Publishedonline:3August2012#S

2、pringerScience+BusinessMedia,LLC2012AbstractGlioblastomaisakindofhighlyaggressiveandpromotingcellmigrationandinvasion,andtheseeffectsincurabletumorwithanaveragesurvivaltimeof12monthsmightbemediatedbyN-cadherinandMMP-2.inourcurrentlyavailabletreatment.

3、TheinvasivecellsarethesourcesoftumorrecurrenceandmechanismsofinvasionKeywordsGlioblastoma.Bex2.Invasion.Migration.arelargelyunknown.Identificationofcandidategenesim-N-cadherin.Metalloproteinase-2portantforinvasionandmigrationisahotspotofcancerbiology.

4、AsonememberofBexproteinfamily,Bex2hasitsfunctionsinthedevelopmentofthenervoussystemandIntroductionneurologicaldiseases.Bex2playsgreatrolesinbreastcan-cer,butitsfunctionandmechanismsingliomaprogressionMalignantbraintumorsarethemostcommonandlethalremain

5、unclear.Inthisstudy,wefoundBex2overexpressionintracranialtumorsandremaindifficulttocuredespitepromotedcellmigrationandinvasion,whileBex2down-advancesinsurgeryandadjuvanttherapy(Ramplingetal.regulationinhibitedthem.Meanwhile,weobservedthat2004;Bucknere

6、tal.2007).AsisreportedbytheAmericanBex2downregulationincreasedN-cadherinbutdecreasedCancerSociety,about13,000AmericansdiesfromsuchtheexcretionofMMP-2.Takentogether,thesedatasug-diseaseseachyearwiththeaveragesurvivaltimefromgestedthatBex2promotedthepro

7、gressionofgliomabydiagnosistodeathbeingapproximately12months(Siebzehnrubletal.2011).ThesetumorsareoneofthemostlethaltumorsbecausethetumorcellsinvadeextensivelyXiupingZhouandXuebinXu-contributedequallytothiswork.intothenearbynormalbraintissuesleadingto

8、recurrenceX.Zhou:Q.Meng:J.Hu:Q.Shi:R.Yu(*)ofthetumor(Lacroixetal.2001).Therefore,themecha-DepartmentofNeurosurgery,AffiliatedHospitalofXuzhounismsbywhichmalignantgliomainvadesextensivelyMedicalCollege,throughoutthebrainparenchymaareprimarytarg