血液透析患者褪黑素水平与氧化应激、炎症状态及睡眠质量相关性分析

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1、授予单位代码10089学号或申请号13523K处(E搿大凌HebeiMedicalUniversity硕士学位论文在职科学学位血液透析患者褪黑素水平与氧化应激、炎症状态及睡眠质量相关性分析学位申请人：赵景新导师：曾文主任医师专业：内科学二级学院：北京市垂杨柳医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始

2、数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名：、导师签章：二级学院领导盖章：汀年r月夕日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章目录中文摘要··············································································1英文摘要···········

3、···································································3英文缩写··············································································5研究论文血液透析患者褪黑素水平与氧化应激、炎症状态及睡眠质量相关性分析前言··············································································6材料与方法············

4、·························································7结果·············································································17附图·············································································19附表······························································

5、···············21讨论·············································································26结论·············································································28参考文献·······································································29综述褪黑素抗氧化作用机制研究进展············

6、··························31致谢···················································································37个人简历·············································································38中文摘要血液透析患者褪黑素水平与氧化应激、炎症状态及睡眠质量相关性分析摘要目的：维持性血液透析（Maintenancehemodialysis，MHD）患者常处于氧化应激（

7、Oxidativestress）及微炎症状态，多合并睡眠障碍。松果体分泌的褪黑素（Melatonin，MT）除具有调节人体觉醒功能外还具有强大的抗氧化、抗炎作用。本研究通过检测维持性血液透析患者血清褪黑素水平、睡眠质量、氧化应激和炎症水平，来探讨血清褪黑素水平与维持性血液透析患者睡眠障碍、氧化应激及微炎症状态的关系。方法：选择42例维持性血液透析患者，于透析前空腹抽取静脉血，以同期查体的20例健康志愿者为正常对照组。采用ELISA检测血清褪黑素（Melatonin，MT），白介素6（Interleukin6，IL-6）水平；采用比色法检测丙二醛（Malondia

8、ldehyde，MDA）