秦皮药代动力学及秦皮接骨胶囊质量控制方法研究

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1、授予单位代码10089学号或申请号20122682H妗(E科大迳HebeiMedicalUniversity硕士学位论文科学学位秦皮药代动力学及秦皮接骨胶囊质量控制方法研究研究生：赵敏敏导师：王巧教授专业：药物分析学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文是在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相

2、应的法律责任。研究生签名师签章：河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人已发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要............................................................................................................1英文摘要.................................................

3、...........................................................6英文缩写..........................................................................................................14研究论文秦皮药代动力学及秦皮接骨胶囊质量控制方法研究引言...........................................................................................

4、...............15第一部分基于液质联用技术的秦皮药物动力学研究第一节秦皮在大鼠血浆中的药物动力学研究·········································17前言········································································································17材料与方法·············································································

5、················17结果········································································································22第二节秦皮在大鼠尿液和胆汁中的排泄动力学研究·····························25前言········································································································25材料与方

6、法·····························································································25结果········································································································29附图·····················································································

7、···················31附表········································································································37讨论········································································································53小结···············