瑞舒伐他汀对uuo大鼠模型肾组织ho-1及tgf-β1，α-sma表达的影响

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1、授予单位代码10089学号或申请号13468HebeiMedicalUniversity硕士学位论文在职科学学位瑞舒伐他汀对UUO大鼠模型肾组织HO-1及TGF-pi�a-SMA表达的影响学位申请人：代翠导师：王保兴教授专业：内科学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有

2、。否则,承担相应法律责任。研究生签名：导师签章二级学院领导盖章：t-U>1X年（月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：,(4)年月I》日目录中文摘要·················································································1英文摘要···························

3、···················································4研究论文瑞舒伐他汀对UUO大鼠模型肾组织HO-1及TGF-β1，α-SMA表达的影响前言········································································9材料与方法···································································10结果···············································

4、····························14附图···········································································16附表·············································································36讨论······································································38结论··························

5、············································42参考文献···································································43综述血红素加氧酶-1及其诱导剂在肾脏疾病的作用研究进展··········46致谢·············································································56个人简历·················································

6、·····························57中文摘要瑞舒伐他汀对UUO大鼠模型肾组织HO-1及TGF-β1，α-SMA表达的影响摘要目的：肾间质纤维化是几乎所有慢性肾脏疾病发展至终末期肾脏病的共同通路。肾间质纤维化是以肾小管基底膜的增厚、肾间质成分增多及基质沉积为主要表现，其病理发展过程涉及炎症反应、氧化应激、多种细胞因子及多种信号通路、细胞凋亡、成纤维细胞增殖和活化及上皮细胞向成纤维细胞转分化等多因素作用。血红素加氧酶（hemeoxygenase,HO)是血红素分解代谢过程中的起始酶和限速酶，以往的研究发现，HO有三种同工酶，分别为HO-1、HO-2、HO-

7、3，其中HO-1极易被诱导表达发挥多种生物学作用。HO-1存在于哺乳动物(包括人)的多种组织细胞的微粒体中，正常情况下，在某些特定器官或组织微量表达或不表达，以脾脏表达最高。在肾脏组织主要表达于皮质肾单位的近端、远端小管、髓质的集合管上皮细胞。过去已有大量研究表明，HO-1及血红素分解代谢的胆绿素、CO、2+Fe均能起到抗炎、抗氧化应激、抗细胞凋亡、调节细胞增殖等保护作用，而肾间质纤维化亦涉及炎症、氧化应激、细胞凋亡等多因素作用。这说明HO-1可能通过其生物学功能发挥抗肾间质纤维化作用。国外