人工真皮联合自体薄层皮片移植修复糖尿病足创面的临床研究

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1、GuangxiMedicalUniversity学号:200890015硕士学位论文人工真皮联合自体薄层皮片移植修复糖尿病足创面的临床研究范丹晨导师姓名：蒙诚跃专业名称：外科学申请学位类型：专业学位答辩委员会主席：刘达恩答辩委员会委员：殷国前刘丹龙李德绘黎宁二•一五年五月原创性声明本人声明所呈交的学位论文是本人在导师指导下进行的研究工作及取得的研究成果。据我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人已经发表或撰写过的研究成果，也不包含获得广两医科大学或其他教育机构的学位或证IH史用过的材料。与我同工作的同志对本研

2、究所做的任何贡献均已在论文中作了明确的说明并表示谢意。学位论文作者签名：签字日期：7^/r年义月&日学位论文版权使用授权书本学位论文作养完全了解学校有关保留、使用学位论文的规定，即：在校期间论文的知识产权属广西医科大学。学校冇权保存论文的电子和纸质文档，可以借阅或上IM公布本论文的部分或全部内容，可以釆用影印、复印或其它手段保存、汇编本论文，学校可以向国家有关机关或机构送交论文的电子和纸质文杓，允许论文被査阅和借阅。的全部或部分内容。保密论文在解密后遵守此规定。M意广西医科大学可以用不同方式在不同媒体上发表、传播学位论文学位论文作

3、者签名：课讀异师签字：签字日期：P…年f月P日签字卜」期夂kT年"月^曰目录一、中文摘要„„„„„„„„„„„„„„„„„„„„„„„„„„1二、英文摘要„„„„„„„„„„„„„„„„„„„„„„„„„„2三、前言„„„„„„„„„„„„„„„„„„„„„„„„„„„„3四、资料和方法„„„„„„„„„„„„„„„„„„„„„„„„„4五、结果„„„„„„„„„„„„„„„„„„„„„„„„„„„„6六、讨论„„„„„„„„„„„„„„„„„„„„„„„„„„„11七、结论„„„„„„„„„„„„„„„„„„„„„„„„„„„1

4、4八、综述„„„„„„„„„„„„„„„„„„„„„„„„„„„15九、参考文献„„„„„„„„„„„„„„„„„„„„„„„„„24十、致谢„„„„„„„„„„„„„„„„„„„„„„„„„„„27人工真皮联合自体薄层皮片移植修复糖尿病足创面的临床研究2015届硕士研究生学位论文人工真皮联合自体薄层皮片移植修复糖尿病足创面的临床研究摘要目的观察人工真皮联合自体薄层皮片移植（以下简称复合皮移植）修复糖尿病足创面的临床疗效。方法收集住院采用复合皮移植手术方法治疗的糖尿病足患者4例，入院后按照营养科制定的糖尿病餐方案用餐，控制血糖在7

5、-10mmol/L,创面每日用磺胺嘧啶银冷霜外敷换药，静脉滴注抗生素控制感染，经清创术后移植人工真皮,1-2周后待人工真皮存活，局部肉芽组织生长良好，外露肌腱被类真皮组织覆盖，二期移植自体薄层皮片修复创面。观察复合皮移植成活率、瘢痕增生情况、色素沉着程度和创面细菌培养等指标，综合评价复合皮移植修复糖尿病足创面的临床疗效。结果4例患者所植人工真皮均存活，存活率98%，其中有3例所植复合皮完全成功存活，1例复合皮大部分成功存活，存活率达95%。术后随访复合皮表面光滑完整，耐磨、质量好，无明显瘢痕增生，有少量色素沉着或色素减退。结论复合

6、皮移植修复糖尿病足创面成功率高，创面愈合质量好，治疗方法较简便，对患者损伤小，瘢痕增生较轻，是一种可用的简便有效的治疗糖尿病足新方法。关键词人工真皮，糖尿病足，自体薄层皮片移植1人工真皮联合自体薄层皮片移植修复糖尿病足创面的临床研究2015届硕士研究生学位论文CLINICALSTUDYOFARTIFICIALDERMISCOMBINATIONWITHAUTOLOGOUSTHINLAYERSKINGRAFTSRAPAIRINGDIABETICFOOTWOUNDABSTRACTObjectiveToobservethetherapye

7、ffectsofartificialdermiscombiningwithautologousthinlayerskingrafts(compositeskingrafts)intreatingthediabeticfootwounds.Methods4caseswithdiabeticfootwhohadtakencompositeskingraftingoperationwereinvolvedinthisstydy.Firstly,diabeticfootwoundinfectionwascontrolledbyusinga

8、ntibioticsandthedebridementswereperformed,thengraftingartificialdermisonthewounds.1-2weekslateaftergraftingartificialdermis,