脂联素通过抑制NLRP3炎症小体激活减轻糖尿病血管内皮损伤

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1、分类号R543.1UDC616.1密级公开脂联素通过抑制NLRP3炎症小体激活减轻糖尿病血管内皮损伤张静隆学号2142013432培养类别全日制学位类型学术学位一级学科(专业类)临床医学二级学科(专业)内科学（心血管病）研究方向糖尿病血管内皮损伤机制指导教师陶凌教授（主任医师）培养单位西京医院心血管内科二O一六年五月目录缩略语表·····························································································-1-中文摘

2、要····························································································-3-英文摘要····························································································-7-前言···································································

3、·······················-12-文献回顾··························································································-14-正文······························································································18第一部分NLRP3炎症小体激活引起糖尿病血管内皮功能障碍·············

4、·········181.材料···························································································182.方法···························································································193.结果·······················································

5、····································254.讨论···························································································30第二部分脂联素通过抑制NLRP3炎症小体激活减轻糖尿病血管内皮损伤及机制研究···························································································

6、···321.材料···························································································322.方法···························································································333.结果·····························································

7、······························384.讨论···························································································47小结······························································································50参考文献·································

8、·····························································51个人简历和研究成果···············································································6