口腔冷疗应用于骨髓移植病人口腔黏膜炎的临床研究

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1、授予单位代码10089学号或申请号13725HebeiMedicalUniversity硕士学位论文在职科学学位口腔冷疗应用于骨髓移植病人口腔黏膜炎的临床研究学位申请人：苏晓倩导师：吴爱须教授专业：护理学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相

2、应法律责任。研究生签名导师签章：二级学院领导盖章：年月硌日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：芽^

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4、：导师签章:y年y月日目录中文摘要·············································································1英文摘要·············································

5、································3研究论文口腔冷疗应用于骨髓移植病人口腔黏膜炎的临床研究前言·············································································6材料与方法····································································7结果·············································································1

6、0附图·············································································13附表·············································································14讨论·············································································18结论················································

7、·····························21参考文献·······································································21综述冷疗法应用在化疗所致口腔黏膜炎的研究现状····················25致谢···················································································31个人简历···················································

8、··························32中文摘要口腔冷疗应用于骨髓移植病人口腔黏膜炎的临床研究摘要目的：通过观察冷疗护理对预防进行骨髓移植的患者发生口腔黏膜炎（oralmucositis，OM）的临床效果，寻觅冷疗护理干预最适合的持续时间，探寻最有效的口腔冷疗方法，降低患者在移植过程中OM的产生率，改善患者的生活质量，并探讨口腔冷疗是否会引起腹泻等其它副作用，为建立骨髓移植病人口腔冷疗护理的临床路径提供有力的证据。方法：本研究为前瞻性随机试验，研究对象为在河北医科大学第二医院血液内科进行首次骨髓移植，年龄为14岁以上读写能力正常并且移植前检查无溃疡、口腔感染等，移植

9、方案为以白消安（Bu）+环磷酰胺（Cy）为基础的恶性血液病患者，共60名病人。本研究所有研究对象进行移植过程中均予每日二次口腔护理常规+漱口水漱口，采用随机数字表法将病人分为三组：试验组（1），试验组（2）与对照组。由于环磷酰胺输注时间为2小时，据此，试验组（1）从病人输注环磷酰胺起就给予口腔冷疗护理，直到环磷酰胺输毕停止，时长为2小时，共20例患者；由于环磷酰胺为活性代谢物，药物清除半衰期为7小时，据此，试验组（2）的口腔冷疗护理时间从开始输注环磷酰胺，直到药物代谢