wnt1和lgr5在卵巢上皮性癌组织中的表达及意义

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1、授予单位代码10089学号或申请号20123156蚵妗(E搿大迳HebeiMedicalUniversity硕士学位论文专业学位Wntl和Lgr5在卵巢上皮性癌组织中的表达及意义研究生：李娅茹导师：冯玉珍教授专业：妇产科学二级学院：第三医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北

2、医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名鈕&导师签章:�si二级学院领导盖章:河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：7!姓&导师签章：m年》月巧日目录中文摘要··················································

3、···························1英文摘要·············································································4英文缩写·············································································8研究论文Wnt1和Lgr5在卵巢上皮性癌组织中的表达及意义前言······································

4、·······································9材料与方法····································································10结果·············································································14附图·······························································

5、··············17附表·············································································20讨论·············································································25结论·············································································30参考

6、文献·······································································30综述Lgr5与卵巢癌关系的研究进展·········································35致谢···················································································42个人简历···································

7、··········································43中 文 摘 要 Wnt1和Lgr5在卵巢上皮性癌组织中的表达及意义摘要目的：卵巢癌(ovariancancer)是女性生殖器官三大恶性肿瘤之一，其中上皮性肿瘤是最常见的病理类型，其发病率次于子宫颈癌和子宫内膜癌列居第三位，但致死率居妇科恶性肿瘤之首，严重威胁着妇女的生命和健康。在卵巢癌的早期阶段，患者常无症状且缺乏有效的诊断手段，大部分患者确诊时已处于疾病的晚期，经治疗后又因肿瘤的复发和化疗耐药，5年生存率仍低于30%。因此，解决

8、早期诊断以及复发和化疗耐药等问题成为改善卵巢癌患者预后的关键。卵巢上皮性癌(Epithelialovariancancer,EOC)是一组高异质性肿瘤，其组织来源尚不明确。肿瘤干细胞(CancerStemCells,CSCs)假说是近年来提出的新理论，认为肿瘤干细胞是存在于肿瘤组织中的一类细胞亚群，与正常干细胞相似，具有自我更新、多向分化潜能和