sd大鼠脑年龄相关性改变—磁共振扩散峰度成像研究

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1、授予单位代码10089学号或申请号20122丨09HebeiMedicalUniversity%}硕士学位论文科学学位SD大鼠脑年龄相关性改变一磁共振扩散峰度成像研究研究生：韩学芳导师：耿左军教授专业：影像医学与核医学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报

2、的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。„,•二•二>I-v•研究生签名导师签章：「二级学院领导盖章：祷終…曰巧河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：>/>：年》月“日目录中文摘要·······································································

3、·······1英文摘要··············································································4英文缩写··············································································8研究论文SD大鼠脑年龄相关性改变—磁共振扩散峰度成像研究前言········································································

4、······9材料与方法·····································································9结果·············································································13附图·············································································18附表······························

5、···············································20讨论·············································································26结论·············································································33参考文献·····························································

6、··········34综述磁共振扩散峰度成像在中枢神经系统中的应用····················39致谢···················································································49个人简历·············································································50中文摘要SD大鼠脑年龄相关性改变—磁共振扩散峰度成像研究摘要目的：应用DKI技术，评价SD大鼠脑增龄

7、性改变过程中灰质、白质、脑脊液的弥散特性及其与年龄的相关性改变。方法：雄性SD大鼠按月龄分5组：3月龄、6月龄、10月龄、13月龄、24月龄（每组各10只），其中24月龄SD大鼠由3月龄SD大鼠连-1-1续颈背部皮下注射D-半乳糖300mg•kg•d，6周获得，注射药物前后均行眼眶取血，检测血浆的SOD活化力及MDA含量，注射药物后SOD活力降低，MDA含量增加（P<0.05）代表24月龄SD大鼠衰老模型造模成功。50只SD大鼠均行颅脑常规MRI及DKI检查，手工绘制感兴趣区，测量胼胝体、两侧外囊、两侧皮层灰质、两侧尾壳核、两侧脑脊液的MK、K∥

8、、K⊥、MD、FA值。应用SPSS17.0软件进行统计分析。外囊、皮层灰质、尾壳核、脑脊液的不同侧别间各统计指标的比较采用配对t检验；采