nrf2are通路在肾间质纤维化中的表达及丁苯肽的肾保护作用

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1、授予单位代码10089学号或申请号13872_HebeiMedicalUniversity硕士学位论文在职科学学位Nrf2/ARE通路在肾间质纤维化中的表达及丁苯肽的肾保护作用学位申请人：曹义甫导师：王秀芬教授专业：内科学2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下,由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、

2、原始数据、申报的专利等知识产权均归河北医科大学所有^否则,承担相应法律责任。研究生签名：导师签章二级学院领导盖章：^年艾月日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。研究生签名：导师签章：X年女月）祀目录中文摘要··································································

3、···········1英文摘要·············································································5英文缩写·············································································9研究论文Nrf2/ARE通路在肾间质纤维化中的表达及丁苯肽的肾保护作用前言·················································

4、····························10材料与方法····································································10结果·············································································23附图··········································································

5、···26附表·············································································45讨论·············································································51结论·············································································55参考文献··········

6、·····························································55综述Nrf2/ARE通路与肾间质纤维化相关研究进展······················57致谢···················································································64个人简历···························································

7、··················65中文摘要Nrf2/ARE通路在肾间质纤维化中的表达及丁苯肽的肾保护作用摘要目的：肾间质纤维化（renalinterstitialfibrosisRIF）是指由多种原因引起的细胞外基质成分（ECM）在肾间质内过度沉积，是各种慢性肾脏疾病进行性发展的共同病理基础。目前其发病机制尚未完全阐明。现有研究证明，氧化应激损伤在肾间质纤维化发病过程中起重要作用，抗氧化能有效延缓肾间质纤维化进程。近些年人们研究发现Keap1-Nrf2-ARE信号通路介导并激活多种抗氧化基因和II相解毒酶基因的转

8、录，从而减轻ROS和亲电子物质引起的细胞损伤，这一信号通路在机体抗氧化应激、抗肿瘤、抗衰老、保护缺血再灌注组织等方面中发挥重要作用。然而Keap1-Nrf2-ARE信号通路在肾间质纤维化中的作用尚未见报道。丁苯肽是一种抗氧化应激药物，广泛用于缺血性脑损伤的治疗，但目前关于丁苯酞在梗阻性肾病小鼠模型中抗氧化应激作用的研究在国内尚无报