hedgehog信号通路在大鼠急性胰腺炎中的作用及其对tnf-α、il-10的影响

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1、授予单位代码10089学号或申请号20122005HebeiMedicalUniversity硕士学位论文科学学位Hedgehog信号通路在大鼠急性胰腺炎中的作用及其对TNF-a�IL-10的影响研究生：李玉娟导师：冯志杰教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署

2、名为单位河北医科大学，试验材料、.原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担应珐彳i责任。研究生签名：虏主4导师签章：年切.厶日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：爲k喪导师签章：目录中文摘要··························································

3、···················1英文摘要·············································································4英文缩写·············································································8研究论文Hedgehog信号通路在大鼠急性胰腺炎中的作用及其对TNF-α、IL-10的影响前言································

4、·············································10材料与方法····································································11结果·············································································18附图··························································

5、···················20附表·············································································24讨论·············································································26结论·············································································3

6、1参考文献·······································································32综述Hedgehog信号通路与胰腺疾病········································35致谢···················································································47个人简历·································

7、············································48中文摘要Hedgehog信号通路在大鼠急性胰腺炎中的作用及其对TNF-α、IL-10的影响摘要急性胰腺炎(acutepancreatitis,AP)是临床常见急腹症，具有起病急、病情重、变化快等特点，除了胰腺本身病变之外，还可能引起胰腺外器官和组织的损伤，甚至最终或可诱发全身炎症反应综合征(systemicinflammatoryresponsesyndrome,SIRS)、多器官功能障碍综合征(multiple-organdys

8、functionsyndrome,MODS)等而导致死亡。目前，关于AP发生发展机制的研究很多，细胞内信号通路即为其中重要的一个方面。大量研究发现，Hedgehog(Hh)信号通路作为细胞内信号通路的新热点，不仅在动物胚胎发育、细胞分化增殖、器官发育调节等生理过程中发挥着重要作用，还与许多疾病的发生发展有着直接的关系