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ID:34747615
大小:1.90 MB
页数:44页
时间:2019-03-10
《门冬氨酸钾镁在冷晶体停搏液中的心肌保护作用》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中文摘要目录英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯。2符号说明⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯。3—1£·—j一日!I舌⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·4材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯8结果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..11讨论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯..13结论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯
2、⋯。27参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯28综烫罡⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯”3l至l[谢⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯“4l攻读学位期问发表的学术论文⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯。42原创性声明⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯43门冬氨酸钾镁在冷晶体停搏液中的心肌保护作用研究生:董经光专业:心外科导师:马胜军教授中文摘要目的验证门冬氨酸钾镁(进口商品名为潘南金PMA)在冷晶体停搏液中的心肌保护作用,从
3、而改善冷晶体停搏液配方,以得到更好的心肌保护效果服务于临床。方法选取1.5岁患有先天性心脏病室间隔缺损20名需要补片修补室间隔缺损病儿,随机分为潘南金停搏液组(A组)及传统的St.Thomas冷晶体停搏液组(B组),潘南金组停搏液配方为,加入40毫升潘南金代替St.Thomas停搏液中的氯化钾,比较心脏停搏前及心脏复苏后的心肌酶差异,自动复跳率、呼吸机辅助时问,心律失常的发生率等指标。结果两组无死亡病例。A组的自动复跳率(100%),明显高于B组(60%)(p4、B水平从术后3h即升高到高峰,术后24小时下降,在术后第3天逐渐恢复。A组与B组比较,A组在术后3h、24h的CTnI和CKMB水平明显降低(p<0.05)。术后心律失常的发生率A组也明显低于B组(p5、IUMDI瓜INGCoOLCRYSTALLOIDCARDIOPLEGIAPostgraduate:Dongjing-guangTutor:Prof.MaSheng-junMajor:CadiovascularSurgeryABSTRACTobjectiveToevaluatetheprotectiveeffectofpotassiummagnesiumaspartate(PMA)onmyocardiumduringcoolcrystaUoidcardioplegia,SOwecanimprovetheprotectionofmyocardialbycha6、ngingtheconstitution.MethodsTwentypatientsunderventricularseptaldefectfromonetofiveyearsoldwhichneedtoreceivepatchrepairedweredividedintotwogroupsrandomly:groupAandgroupB.ThepatientsingroupBreceivedroutinecoolcardioplegia,andingroupAWaSinsteadbycoolcardioplegiathatpotassiumchlori7、deisreplacedby40mlPMA.Thefollowingparameterswererecordedtoevaluatethesafetyandefficacy:differencesincardiacenzymes、therateofre—beatingandarrhythmiaandVentilationtime.Results’nThereWaSnodeathsinthetwogroups.Therateofre—beringingroupAwashigherthanthatingroupB(P<0.05);TheplasmacTnI、8、cTnTandCKMBlevelofthetwogroupsincreaseda
4、B水平从术后3h即升高到高峰,术后24小时下降,在术后第3天逐渐恢复。A组与B组比较,A组在术后3h、24h的CTnI和CKMB水平明显降低(p<0.05)。术后心律失常的发生率A组也明显低于B组(p5、IUMDI瓜INGCoOLCRYSTALLOIDCARDIOPLEGIAPostgraduate:Dongjing-guangTutor:Prof.MaSheng-junMajor:CadiovascularSurgeryABSTRACTobjectiveToevaluatetheprotectiveeffectofpotassiummagnesiumaspartate(PMA)onmyocardiumduringcoolcrystaUoidcardioplegia,SOwecanimprovetheprotectionofmyocardialbycha6、ngingtheconstitution.MethodsTwentypatientsunderventricularseptaldefectfromonetofiveyearsoldwhichneedtoreceivepatchrepairedweredividedintotwogroupsrandomly:groupAandgroupB.ThepatientsingroupBreceivedroutinecoolcardioplegia,andingroupAWaSinsteadbycoolcardioplegiathatpotassiumchlori7、deisreplacedby40mlPMA.Thefollowingparameterswererecordedtoevaluatethesafetyandefficacy:differencesincardiacenzymes、therateofre—beatingandarrhythmiaandVentilationtime.Results’nThereWaSnodeathsinthetwogroups.Therateofre—beringingroupAwashigherthanthatingroupB(P<0.05);TheplasmacTnI、8、cTnTandCKMBlevelofthetwogroupsincreaseda
5、IUMDI瓜INGCoOLCRYSTALLOIDCARDIOPLEGIAPostgraduate:Dongjing-guangTutor:Prof.MaSheng-junMajor:CadiovascularSurgeryABSTRACTobjectiveToevaluatetheprotectiveeffectofpotassiummagnesiumaspartate(PMA)onmyocardiumduringcoolcrystaUoidcardioplegia,SOwecanimprovetheprotectionofmyocardialbycha
6、ngingtheconstitution.MethodsTwentypatientsunderventricularseptaldefectfromonetofiveyearsoldwhichneedtoreceivepatchrepairedweredividedintotwogroupsrandomly:groupAandgroupB.ThepatientsingroupBreceivedroutinecoolcardioplegia,andingroupAWaSinsteadbycoolcardioplegiathatpotassiumchlori
7、deisreplacedby40mlPMA.Thefollowingparameterswererecordedtoevaluatethesafetyandefficacy:differencesincardiacenzymes、therateofre—beatingandarrhythmiaandVentilationtime.Results’nThereWaSnodeathsinthetwogroups.Therateofre—beringingroupAwashigherthanthatingroupB(P<0.05);TheplasmacTnI、
8、cTnTandCKMBlevelofthetwogroupsincreaseda
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