性激素代谢及血管生成通路相关基因多态性与子痫前期发病关系研究

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1、分类号：R181学校代码：10114密级：学号：Dr2012046性激素代谢及血管生成通路相关基因多态性与子痫前期发病关系研究Associationbetweensexhormonemetabolismandangiogenicpathwaygenespolymorphismwithpreeclampsia研究生：张萍指导教师：王素萍教授专业名称：流行病与卫生统计学研究方向：慢性非传染病流行病学学位类型：科学学位所在学院：公共卫生学院中国山西二O一八年六月一日目录中文摘要....................................................

2、...................................................................IAbstract......................................................................................................................VI常用缩写词中英文对照表...................................................................................

3、.....XI前言.......................................................................................................................1第一部分性激素代谢通路相关基因多态性与子痫前期关系研究.........................51研究背景.......................................................................................................

4、............52对象与方法...............................................................................................................72.1研究对象及基本信息.........................................................................................72.2生物样品的采集...............................................

5、..................................................82.3性激素代谢通路基因多态性检测.....................................................................82.4性激素代谢相关基因多态性测定.....................................................................92.5统计分析方法........................................................

6、...........................................102.6基因多态性位点功能预测方法.......................................................................113结果.....................................................................................................................123.1一般情况及子痫前期影响因素单因素分析.............

7、......................................123.2性激素代谢通路基因与子痫前期及亚型发病风险关联性分析...................173.3性激素代谢通路相关基因多态性与子痫前期及其临床亚型发病风险关联性分析......................................................................................................................183.4性激素代谢通路基因与